TY  - JOUR
AU  - Landry, J.
TI  - The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
JA  - Proc. Natl Acad. Sci. USA
PY  - 2000///
VL  - 97
SP  - 5807
EP  - 5811
PB  - Nature Publishing Group
M3  - 10.1073/pnas.110148297
N1  - 10.1073/pnas.110148297
UR  - http://dx.doi.org/10.1073/pnas.110148297
ER  -

TY  - JOUR
AU  - Imai, S.
AU  - Armstrong, C. M.
AU  - Kaeberlein, M.
AU  - Guarente, L.
TI  - Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
JA  - Nature
PY  - 2000///
VL  - 403
SP  - 795
EP  - 800
PB  - Nature Publishing Group
M3  - 10.1038/35001622
N1  - 10.1038/35001622
UR  - http://dx.doi.org/10.1038/35001622
ER  -

TY  - JOUR
AU  - Mostoslavsky, R.
TI  - Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
JA  - Cell
PY  - 2006///
VL  - 124
SP  - 315
EP  - 329
PB  - Nature Publishing Group
M3  - 10.1016/j.cell.2005.11.044
N1  - 10.1016/j.cell.2005.11.044
UR  - http://dx.doi.org/10.1016/j.cell.2005.11.044
ER  -

TY  - JOUR
AU  - Cheng, W. H.
AU  - Muftuoglu, M.
AU  - Bohr, V. A.
TI  - Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase
JA  - Exp. Gerontol.
PY  - 2007///
VL  - 42
SP  - 871
EP  - 878
PB  - Nature Publishing Group
M3  - 10.1016/j.exger.2007.04.011
N1  - 10.1016/j.exger.2007.04.011
UR  - http://dx.doi.org/10.1016/j.exger.2007.04.011
ER  -

TY  - JOUR
AU  - Multani, A. S.
AU  - Chang, S.
TI  - WRN at telomeres: implications for aging and cancer
JA  - J. Cell Sci.
PY  - 2007///
VL  - 120
SP  - 713
EP  - 721
PB  - Nature Publishing Group
M3  - 10.1242/jcs.03397
N1  - 10.1242/jcs.03397
UR  - http://dx.doi.org/10.1242/jcs.03397
ER  -

TY  - JOUR
AU  - Campisi, J.
TI  - Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
JA  - Cell
PY  - 2005///
VL  - 120
SP  - 513
EP  - 522
PB  - Nature Publishing Group
M3  - 10.1016/j.cell.2005.02.003
N1  - 10.1016/j.cell.2005.02.003
UR  - http://dx.doi.org/10.1016/j.cell.2005.02.003
ER  -

TY  - JOUR
AU  - Verdun, R. E.
AU  - Karlseder, J.
TI  - Replication and protection of telomeres
JA  - Nature
PY  - 2007///
VL  - 447
SP  - 924
EP  - 931
PB  - Nature Publishing Group
M3  - 10.1038/nature05976
N1  - 10.1038/nature05976
UR  - http://dx.doi.org/10.1038/nature05976
ER  -

TY  - JOUR
AU  - van Overbeek, M.
AU  - de Lange, T.
TI  - Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S[thinsp]phase
JA  - Curr. Biol.
PY  - 2006///
VL  - 16
SP  - 1295
EP  - 1302
PB  - Nature Publishing Group
M3  - 10.1016/j.cub.2006.05.022
N1  - 10.1016/j.cub.2006.05.022
UR  - http://dx.doi.org/10.1016/j.cub.2006.05.022
ER  -

TY  - JOUR
AU  - Takai, H.
AU  - Smogorzewska, A.
AU  - de Lange, T.
TI  - DNA damage foci at dysfunctional telomeres
JA  - Curr. Biol.
PY  - 2003///
VL  - 13
SP  - 1549
EP  - 1556
PB  - Nature Publishing Group
M3  - 10.1016/S0960-9822(03)00542-6
N1  - 10.1016/S0960-9822(03)00542-6
UR  - http://dx.doi.org/10.1016/S0960-9822(03)00542-6
ER  -

TY  - JOUR
AU  - d/'Adda di Fagagna, F.
TI  - A DNA damage checkpoint response in telomere-initiated senescence
JA  - Nature
PY  - 2003///
VL  - 426
SP  - 194
EP  - 198
PB  - Nature Publishing Group
M3  - 10.1038/nature02118
N1  - 10.1038/nature02118
UR  - http://dx.doi.org/10.1038/nature02118
ER  -

TY  - JOUR
AU  - van Steensel, B.
AU  - Smogorzewska, A.
AU  - de Lange, T.
TI  - TRF2 protects human telomeres from end-to-end fusions
JA  - Cell
PY  - 1998///
VL  - 92
SP  - 401
EP  - 413
PB  - Nature Publishing Group
M3  - 10.1016/S0092-8674(00)80932-0
N1  - 10.1016/S0092-8674(00)80932-0
UR  - http://dx.doi.org/10.1016/S0092-8674(00)80932-0
ER  -

TY  - JOUR
AU  - Sherr, C. J.
AU  - DePinho, R. A.
TI  - Cellular senescence: mitotic clock or culture shock?
JA  - Cell
PY  - 2000///
VL  - 102
SP  - 407
EP  - 410
PB  - Nature Publishing Group
M3  - 10.1016/S0092-8674(00)00046-5
N1  - 10.1016/S0092-8674(00)00046-5
UR  - http://dx.doi.org/10.1016/S0092-8674(00)00046-5
ER  -

TY  - JOUR
AU  - Crabbe, L.
AU  - Verdun, R. E.
AU  - Haggblom, C. I.
AU  - Karlseder, J.
TI  - Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
JA  - Science
PY  - 2004///
VL  - 306
SP  - 1951
EP  - 1953
PB  - Nature Publishing Group
M3  - 10.1126/science.1103619
N1  - 10.1126/science.1103619
UR  - http://dx.doi.org/10.1126/science.1103619
ER  -

TY  - JOUR
AU  - Laud, P. R.
TI  - Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
JA  - Genes Dev.
PY  - 2005///
VL  - 19
SP  - 2560
EP  - 2570
PB  - Nature Publishing Group
M3  - 10.1101/gad.1321305
N1  - 10.1101/gad.1321305
UR  - http://dx.doi.org/10.1101/gad.1321305
ER  -

TY  - JOUR
AU  - Crabbe, L.
AU  - Jauch, A.
AU  - Naeger, C. M.
AU  - Holtgreve-Grez, H.
AU  - Karlseder, J.
TI  - Telomere dysfunction as a cause of genomic instability in Werner syndrome
JA  - Proc. Natl Acad. Sci. USA
PY  - 2007///
VL  - 104
SP  - 2205
EP  - 2210
PB  - Nature Publishing Group
M3  - 10.1073/pnas.0609410104
N1  - 10.1073/pnas.0609410104
UR  - http://dx.doi.org/10.1073/pnas.0609410104
ER  -

TY  - JOUR
AU  - Wyllie, F. S.
TI  - Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
JA  - Nature Genet.
PY  - 2000///
VL  - 24
SP  - 16
EP  - 17
PB  - Nature Publishing Group
M3  - 10.1038/71630
N1  - 10.1038/71630
UR  - http://dx.doi.org/10.1038/71630
ER  -

TY  - JOUR
AU  - Opresko, P. L.
TI  - The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
JA  - Mol. Cell
PY  - 2004///
VL  - 14
SP  - 763
EP  - 774
PB  - Nature Publishing Group
M3  - 10.1016/j.molcel.2004.05.023
N1  - 10.1016/j.molcel.2004.05.023
UR  - http://dx.doi.org/10.1016/j.molcel.2004.05.023
ER  -

TY  - JOUR
AU  - Loayza, D.
AU  - De Lange, T.
TI  - POT1 as a terminal transducer of TRF1 telomere length control
JA  - Nature
PY  - 2003///
VL  - 423
SP  - 1013
EP  - 1018
PB  - Nature Publishing Group
M3  - 10.1038/nature01688
N1  - 10.1038/nature01688
UR  - http://dx.doi.org/10.1038/nature01688
ER  -

TY  - JOUR
AU  - Benetti, R.
AU  - Garcia-Cao, M.
AU  - Blasco, M. A.
TI  - Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
JA  - Nature Genet.
PY  - 2007///
VL  - 39
SP  - 243
EP  - 250
PB  - Nature Publishing Group
M3  - 10.1038/ng1952
N1  - 10.1038/ng1952
UR  - http://dx.doi.org/10.1038/ng1952
ER  -

TY  - JOUR
AU  - Ariyoshi, K.
AU  - Suzuki, K.
AU  - Goto, M.
AU  - Watanabe, M.
AU  - Kodama, S.
TI  - Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells
JA  - J. Radiat. Res. (Tokyo)
PY  - 2007///
VL  - 48
SP  - 219
EP  - 231
PB  - Nature Publishing Group
M3  - 10.1269/jrr.07017
N1  - 10.1269/jrr.07017
UR  - http://dx.doi.org/10.1269/jrr.07017
ER  -

TY  - JOUR
AU  - Takeuchi, F.
AU  - Hanaoka, F.
AU  - Goto, M.
AU  - Yamada, M.
AU  - Miyamoto, T.
TI  - Prolongation of S[thinsp]phase and whole cell cycle in Werner/'s syndrome fibroblasts
JA  - Exp. Gerontol.
PY  - 1982///
VL  - 17
SP  - 473
EP  - 480
PB  - Nature Publishing Group
M3  - 10.1016/S0531-5565(82)80009-0
N1  - 10.1016/S0531-5565(82)80009-0
UR  - http://dx.doi.org/10.1016/S0531-5565(82)80009-0
ER  -

TY  - JOUR
AU  - Poot, M.
AU  - Hoehn, H.
AU  - Runger, T. M.
AU  - Martin, G. M.
TI  - Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
JA  - Exp. Cell Res.
PY  - 1992///
VL  - 202
SP  - 267
EP  - 273
PB  - Nature Publishing Group
M3  - 10.1016/0014-4827(92)90074-I
N1  - 10.1016/0014-4827(92)90074-I
UR  - http://dx.doi.org/10.1016/0014-4827(92)90074-I
ER  -

TY  - JOUR
AU  - Tommerup, H.
AU  - Dousmanis, A.
AU  - de Lange, T.
TI  - Unusual chromatin in human telomeres
JA  - Mol. Cell. Biol.
PY  - 1994///
VL  - 14
SP  - 5777
EP  - 5785
PB  - Nature Publishing Group
ER  -

TY  - JOUR
AU  - Blasco, M. A.
TI  - The epigenetic regulation of mammalian telomeres
JA  - Nature Rev. Genet.
PY  - 2007///
VL  - 8
SP  - 299
EP  - 309
PB  - Nature Publishing Group
M3  - 10.1038/nrg2047
N1  - 10.1038/nrg2047
UR  - http://dx.doi.org/10.1038/nrg2047
ER  -

TY  - JOUR
AU  - Chang, S.
TI  - Essential role of limiting telomeres in the pathogenesis of Werner syndrome
JA  - Nature Genet.
PY  - 2004///
VL  - 36
SP  - 877
EP  - 882
PB  - Nature Publishing Group
M3  - 10.1038/ng1389
N1  - 10.1038/ng1389
UR  - http://dx.doi.org/10.1038/ng1389
ER  -

TY  - JOUR
AU  - Herbig, U.
AU  - Jobling, W. A.
AU  - Chen, B. P.
AU  - Chen, D. J.
AU  - Sedivy, J. M.
TI  - Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
JA  - Mol. Cell
PY  - 2004///
VL  - 14
SP  - 501
EP  - 513
PB  - Nature Publishing Group
M3  - 10.1016/S1097-2765(04)00256-4
N1  - 10.1016/S1097-2765(04)00256-4
UR  - http://dx.doi.org/10.1016/S1097-2765(04)00256-4
ER  -

TY  - JOUR
AU  - Dimitrova, N.
AU  - de Lange, T.
TI  - MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres
JA  - Genes Dev.
PY  - 2006///
VL  - 20
SP  - 3238
EP  - 3243
PB  - Nature Publishing Group
M3  - 10.1101/gad.1496606
N1  - 10.1101/gad.1496606
UR  - http://dx.doi.org/10.1101/gad.1496606
ER  -

TY  - JOUR
AU  - Padilla-Nash, H. M.
TI  - Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms
JA  - Genes Chromosom. Cancer
PY  - 2001///
VL  - 30
SP  - 349
EP  - 363
PB  - Nature Publishing Group
M3  - 10.1002/gcc.1101
N1  - 10.1002/gcc.1101
UR  - http://dx.doi.org/10.1002/gcc.1101
ER  -

TY  - JOUR
AU  - Michishita, E.
AU  - Park, J. Y.
AU  - Burneskis, J. M.
AU  - Barrett, J. C.
AU  - Horikawa, I.
TI  - Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
JA  - Mol. Biol. Cell
PY  - 2005///
VL  - 16
SP  - 4623
EP  - 4635
PB  - Nature Publishing Group
M3  - 10.1091/mbc.E05-01-0033
N1  - 10.1091/mbc.E05-01-0033
UR  - http://dx.doi.org/10.1091/mbc.E05-01-0033
ER  -

TY  - JOUR
AU  - Chua, K. F.
TI  - Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
JA  - Cell Metab.
PY  - 2005///
VL  - 2
SP  - 67
EP  - 76
PB  - Nature Publishing Group
M3  - 10.1016/j.cmet.2005.06.007
N1  - 10.1016/j.cmet.2005.06.007
UR  - http://dx.doi.org/10.1016/j.cmet.2005.06.007
ER  -

TY  - JOUR
AU  - Dimri, G. P.
TI  - A biomarker that identifies senescent human cells in culture and in aging skin in vivo
JA  - Proc. Natl Acad. Sci. USA
PY  - 1995///
VL  - 92
SP  - 9363
EP  - 9367
PB  - Nature Publishing Group
M3  - 10.1073/pnas.92.20.9363
N1  - 10.1073/pnas.92.20.9363
UR  - http://dx.doi.org/10.1073/pnas.92.20.9363
ER  -

TY  - JOUR
AU  - Schrock, E.
TI  - Multicolor spectral karyotyping of human chromosomes
JA  - Science
PY  - 1996///
VL  - 273
SP  - 494
EP  - 497
PB  - Nature Publishing Group
M3  - 10.1126/science.273.5274.494
N1  - 10.1126/science.273.5274.494
UR  - http://dx.doi.org/10.1126/science.273.5274.494
ER  -