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Nature 452, 492-496 (12 March 2008) | doi:10.1038/nature06736;
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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae. In mice, deficiency for the Sir2 family member SIRT6 leads to a shortened lifespan and a premature ageing-like phenotype.
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