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Nature 452, xiii (27 March 2008) | doi:10.1038/7186xiiib; Published online 26 March 2008

Open Innovation Challenges

Abstractions

Susceptibility to many common conditions and diseases, from obesity to cancer, involves the combined effects of many genes and of the many environmental factors that influence how these genes function. On pages 423 and 429, Eric Schadt of Rosetta Inpharmatics in Seattle, Washington, and his colleagues detail an approach to identifying such 'gene networks' — an advance that could potentially lead to diagnostic markers and therapeutic targets for common diseases.