FIGURE 3. Genes in the MEM network validated as having a causal relationship with obesity traits.
From the following article:
Variations in DNA elucidate molecular networks that cause disease
Yanqing Chen, Jun Zhu, Pek Yee Lum, Xia Yang, Shirly Pinto, Douglas J. MacNeil, Chunsheng Zhang, John Lamb, Stephen Edwards, Solveig K. Sieberts, Amy Leonardson, Lawrence W. Castellini, Susanna Wang, Marie-France Champy, Bin Zhang, Valur Emilsson, Sudheer Doss, Anatole Ghazalpour, Steve Horvath, Thomas A. Drake, Aldons J. Lusis & Eric E. Schadt
Nature 452, 429-435(27 March 2008)
doi:10.1038/nature06757
a, The MEMN is enriched for genes supported as having a causal relationship with disease traits in the B 
H cross (red nodes). The black nodes represent genes in the MEMN not supported as causal for disease traits in the B H cross. b, FMLM ratio curves for Lpl knockout (n = 25) and wild-type control (n = 23) mice (P = 1.09 10-5 that the difference at the last time point is significant). c, FMLM ratio curves for the Lactb transgenic (n = 36) and wild-type control (n = 27) mice (P = 4.48 10-5 that the difference at the last time point is significant). d, Weight curves for the Ppm1l-/- (n = 18) and wild-type control (n = 18) mice (P = 1.93 10-11 that the difference at the last time point is significant). Error bars in b–d represent 
1s.d. of the indicated measures based on replicates and signal-to-noise ratios derived from the model applied to the weight and fat mass differences.
