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From the following article:

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Eriko Michishita, Ronald A. McCord, Elisabeth Berber, Mitomu Kioi, Hesed Padilla-Nash, Mara Damian, Peggie Cheung, Rika Kusumoto, Tiara L. A. Kawahara, J. Carl Barrett, Howard Y. Chang, Vilhelm A. Bohr, Thomas Ried, Or Gozani & Katrin F. Chua

Nature 452, 492-496(27 March 2008)

doi:10.1038/nature06736

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

SIRT6 knockdown leads to premature cellular senescence and telomere dysfunction.

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Figure 2

SIRT6 associates with telomeric chromatin.

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Figure 3

SIRT6 deacetylates lysine 9 of histone H3 at telomeric chromatin.

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Figure 4

SIRT6 stabilizes WRN at telomeric chromatin and prevents replication-associated telomere defects.

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