Figures and Tables

From the following article:

A new class of anthelmintics effective against drug-resistant nematodes

Ronald Kaminsky, Pierre Ducray, Martin Jung, Ralph Clover, Lucien Rufener, Jacques Bouvier, Sandra Schorderet Weber, Andre Wenger, Susanne Wieland-Berghausen, Thomas Goebel, Noelle Gauvry, François Pautrat, Thomas Skripsky, Olivier Froelich, Clarisse Komoin-Oka, Bethany Westlund, Ann Sluder & Pascal Mäser

Nature 452, 176-180(13 March 2008)

doi:10.1038/nature06722

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Figure 1

Amino-acetonitrile derivatives (AADs).

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Figure 2

Selected AADs, their structures and the corresponding anthelmintic efficacies in vitro and in vivo.

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Figure 3

Pharmacokinetics of AADs.

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Figure 4

Involvement of nAChRs in AAD resistance.

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Table 1

Efficacy of AADs against adult stages of drug-resistant H. contortus, T. circumcincta and T. colubriformis in sheep

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