Table of contents
Volume 452 Number 7184 pp127-252
(this content only available online) indicates content that is available online only
Editorials
Growing pains p127
The fight against agricultural diseases in the United States has been boosted by fresh funds and a national monitoring network. But these advances are being undermined by inflexible bureaucracy.
doi:10.1038/452127a
Markets can save forests p127
With the right infrastructure, the forces threatening to destroy the world's trees could be their salvation.
doi:10.1038/452127b
On message, off target p128
Official advice on vaccination is too often poorly transmitted.
doi:10.1038/452128a
News
Stem-cell claim gets cold reception p132
Carbon nanotubes used to reprogramme adult human cells?
David Cyranoski & Monya Baker
doi:10.1038/452132a
Pacific "dwarf" bones cause controversy p133
Some researchers think the Palau finds are the remains of youngsters.
Rex Dalton
doi:10.1038/452133a
Brazil goes to war against logging p134
It represents half of the world's rainforest and is home to one-third of Earth's species, yet the Amazon has one of the highest rates of deforestation. Jeff Tollefson looks at efforts to curb the problem.
Jeff Tollefson
doi:10.1038/452134a
All eyes on the Amazon p137
Meteorologist and biosphere scientist Carlos Nobre of Brazil's National Institute for Space Research in São Paulo has modelled the effects of deforestation and global warming on the Amazon. Nature talks to him about the future of the unique rainforest.
Carlos Nobre
doi:10.1038/452137a
Sidelines p138
Scribbles on the margins of science.
doi:10.1038/452138a
Snapshot: Flooding the canyon p138
Water diverted to stir sediments and save chub.
Anna Petherick
doi:10.1038/452138b
Libya progresses on HIV p138
Integrated approach could be model for Africa.
Declan Butler
doi:10.1038/452138c
Probe readies for dip into geyser on Enceladus p139
Astrobiologists hope for clues about moon's temperature.
Eric Hand
doi:10.1038/452139a
Seattle laboratory arsonist faces prison stretch p141
doi:10.1038/452141a
Giant telescope gets double vision p141
doi:10.1038/452141b
Officials downplay vaccine's link with autism p141
doi:10.1038/452141c
British government to demand clinical trial data p141
doi:10.1038/452141d
Jules Verne sets off for space station p141
doi:10.1038/452141e
Charity to focus scientists' skills on the needy p141
doi:10.1038/452141f
Chinese scientists lead panda genome project p141
doi:10.1038/452141g
News Feature
Astronomy: Eyes as big as the sky p142
Three teams are racing each other to build the next generation of telescopes that would dramatically dwarf the largest on Earth today. Eric Hand checks out the competition.
doi:10.1038/452142a
Business Feature
Business: Stepping out p146
A surprisingly large number of university-inspired patents may be going to industry instead. Rex Dalton reports.
Rex Dalton
doi:10.1038/452146a
News Feature
Bioterror: The green menace p148
Huanglongbing, a disease that could devastate the US citrus industry, pits national security against plant pathologists looking to battle natural outbreaks, Ewen Callaway reports.
doi:10.1038/452148a
Correspondence
Poor countries left behind in rush to claim sea floor p151
Morten Sørensen
doi:10.1038/452151a
Directive will unleash new generation of coal polluters p151
Mark Avery, John Sauven, Keith Allot, Benedict Southworth & Andrew Pendleton
doi:10.1038/452151b
How academic corporatism can lead to dictatorship p151
G. A. Clark
doi:10.1038/452151c
Results of rush to sequence genomes may be nonsense p151
Thomas C. Erren, Paul Cullen & Michael Erren
doi:10.1038/452151d
Books and Arts
One long argument p153
Revisiting ancient Greek debates about the natural world should broaden biologists' horizons.
Armand M. Leroi reviews Creationism and its Critics in Antiquity by David Sedley
doi:10.1038/452153a
Storming the language barrier p154
Frans B. M. de Waal reviews The Simian Tongue: The Long Debate about Animal Language by Gregory Radick
doi:10.1038/452154a
Exhibition: A protein ghost etched in glass p155
Marta Paterlini
doi:10.1038/452155a
Census of cyberspace censoring p155
Bruce Schneier reviews Access Denied
doi:10.1038/452155b
Exhibition: Beauty meets utility at MoMA p156
Josie Glausiusz
doi:10.1038/452156a
Correction p156
doi:10.1038/452156b
News and Views
Drug discovery: Fresh hope to can the worms p157
Parasitic worms kill many livestock, and the drugs used against them are becoming less effective. The discovery of a class of compounds that kills worms resistant to existing drugs is thus a welcome development.
Roger K. Prichard & Timothy G. Geary
doi:10.1038/452157a
See also: Editor's summary
Cosmology: Patchy solutions p158
The Universe seems to be expanding ever faster — a phenomenon generally ascribed to the influence of 'dark energy'. But might the observed acceleration be a trick of the light in an inhomogeneous Universe?
George Ellis
doi:10.1038/452158a
50 & 100 Years Ago p159
doi:10.1038/452159a
Physical chemistry: Did life grind to a start? p161
Many solids can adopt two mirror-image crystal forms, and often grow as mixtures of both. A curious mechanism of crystal growth might explain why some mixtures convert into one form when subjected to grinding.
J. Michael McBride & John C. Tully
doi:10.1038/452161a
Nitrogen cycle: Out of reach p162
Denitrifying bacteria and hungry plants do sterling work in disposing of the nitrates that we pump into rivers and streams. But as the excess influx goes up and up, the efficiency of removal goes down and down.
Sybil Seitzinger
doi:10.1038/452162a
Biochemistry: Radicals by reduction p163
Many enzymes convert their substrates into organic radicals to allow challenging reactions to occur. A microbial enzyme does so by simple electron transfer, casting fresh light on enzyme evolution.
Joseph T. Jarrett
doi:10.1038/452163a
News and Views Q&A
Earth science: Geomagnetic reversals p165
Earth's magnetic field is unstable. Not only does it vary in intensity, but from time to time it flips, with the poles reversing sign. Much of this behaviour remains a mystery, but a combination of geomagnetic observations with theoretical studies has been providing enlightenment.
David Gubbins
doi:10.1038/452165a
See also: Editor's summary
Brief Communications Arising
Complex speciation of humans and chimpanzees pE3
John Wakeley
doi:10.1038/nature06805
First paragraph | Full Text | PDF (155K)
Patterson et al. reply pE4
Nick Patterson, Daniel J. Richter, Sante Gnerre, Eric S. Lander & David Reich
doi:10.1038/nature06806
First paragraph | Full Text | PDF (155K)
Review
Genetic basis of fitness differences in natural populations p169
Hans Ellegren & Ben C. Sheldon
doi:10.1038/nature06737
First paragraph | Full Text | PDF (576K)
See also: Editor's summary
Articles
A new class of anthelmintics effective against drug-resistant nematodes p176
Ronald Kaminsky, Pierre Ducray, Martin Jung, Ralph Clover, Lucien Rufener, Jacques Bouvier, Sandra Schorderet Weber, Andre Wenger, Susanne Wieland-Berghausen, Thomas Goebel, Noelle Gauvry, François Pautrat, Thomas Skripsky, Olivier Froelich, Clarisse Komoin-Oka, Bethany Westlund, Ann Sluder & Pascal Mäser
doi:10.1038/nature06722
Abstract | Full Text | PDF (595K) | Supplementary information
See also: News and Views by Prichard & Geary
Pyruvate kinase M2 is a phosphotyrosine-binding protein p181
Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara & Lewis C. Cantley
doi:10.1038/nature06667
Abstract | Full Text | PDF (496K) | Supplementary information
SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis p187
Hye-Jung Han, Jose Russo, Yoshinori Kohwi & Terumi Kohwi-Shigematsu
doi:10.1038/nature06781
Abstract | Full Text | PDF (3,547K) | Supplementary information
See also: Editor's summary
Letters
Reflected light from sand grains in the terrestrial zone of a protoplanetary disk p194
William Herbst, Catrina M. Hamilton, Katherine LeDuc, Joshua N. Winn, Christopher M. Johns-Krull, Reinhard Mundt & Mansur Ibrahimov
doi:10.1038/nature06671
First paragraph | Full Text | PDF (841K) | Supplementary information
See also: Editor's summary
Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra p198
Yu He, Tao Ye, Min Su, Chuan Zhang, Alexander E. Ribbe, Wen Jiang & Chengde Mao
doi:10.1038/nature06597
First paragraph | Full Text | PDF (3,022K) | Supplementary information
See also: Editor's summary
Stream denitrification across biomes and its response to anthropogenic nitrate loading p202
Patrick J. Mulholland, Ashley M. Helton, Geoffrey C. Poole, Robert O. Hall, Stephen K. Hamilton, Bruce J. Peterson, Jennifer L. Tank, Linda R. Ashkenas, Lee W. Cooper, Clifford N. Dahm, Walter K. Dodds, Stuart E. G. Findlay, Stanley V. Gregory, Nancy B. Grimm, Sherri L. Johnson, William H. McDowell, Judy L. Meyer, H. Maurice Valett, Jackson R. Webster, Clay P. Arango, Jake J. Beaulieu, Melody J. Bernot, Amy J. Burgin, Chelsea L. Crenshaw, Laura T. Johnson, B. R. Niederlehner, Jonathan M. O'Brien, Jody D. Potter, Richard W. Sheibley, Daniel J. Sobota & Suzanne M. Thomas
doi:10.1038/nature06686
First paragraph | Full Text | PDF (328K) | Supplementary information
See also: News and Views by Seitzinger
Influence of the Gulf Stream on the troposphere p206
Shoshiro Minobe, Akira Kuwano-Yoshida, Nobumasa Komori, Shang-Ping Xie & Richard Justin Small
doi:10.1038/nature06690
First paragraph | Full Text | PDF (644K) | Supplementary information
See also: Editor's summary
Diversity and productivity peak at intermediate dispersal rate in evolving metacommunities p210
P. A. Venail, R. C. MacLean, T. Bouvier, M. A. Brockhurst, M. E. Hochberg & N. Mouquet
doi:10.1038/nature06554
First paragraph | Full Text | PDF (413K) | Supplementary information
See also: Editor's summary
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning p215
Shawn J. Cokus, Suhua Feng, Xiaoyu Zhang, Zugen Chen, Barry Merriman, Christian D. Haudenschild, Sriharsa Pradhan, Stanley F. Nelson, Matteo Pellegrini & Steven E. Jacobsen
doi:10.1038/nature06745
First paragraph | Full Text | PDF (1,291K) | Supplementary information
See also: Editor's summary
Adaptive coding of visual information in neural populations p220
Diego A. Gutnisky & Valentin Dragoi
doi:10.1038/nature06563
First paragraph | Full Text | PDF (1,479K) | Supplementary information
A skin microRNA promotes differentiation by repressing 'stemness' p225
Rui Yi, Matthew N. Poy, Markus Stoffel & Elaine Fuchs
doi:10.1038/nature06642
First paragraph | Full Text | PDF (838K) | Supplementary information
See also: Editor's summary
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth p230
Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris, Arvind Ramanathan, Robert E. Gerszten, Ru Wei, Mark D. Fleming, Stuart L. Schreiber & Lewis C. Cantley
doi:10.1038/nature06734
First paragraph | Full Text | PDF (488K) | Supplementary information
See also: Editor's summary
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes p234
You-Me Kim, Melanie M. Brinkmann, Marie-Eve Paquet & Hidde L. Ploegh
doi:10.1038/nature06726
First paragraph | Full Text | PDF (563K) | Supplementary information
An allylic ketyl radical intermediate in clostridial amino-acid fermentation p239
Jihoe Kim, Daniel J. Darley, Wolfgang Buckel & Antonio J. Pierik
doi:10.1038/nature06637
First paragraph | Full Text | PDF (352K) | Supplementary information
See also: Editor's summary | News and Views by Jarrett
Transcriptional repression mediated by repositioning of genes to the nuclear lamina p243
K. L. Reddy, J. M. Zullo, E. Bertolino & H. Singh
doi:10.1038/nature06727
First paragraph | Full Text | PDF (589K) | Supplementary information
Erratum
The X-ray crystal structure of RNA polymerase from Archaea p248
Akira Hirata, Brianna J. Klein & Katsuhiko S. Murakami
doi:10.1038/nature06844
PDB code
3D view
Naturejobs
ProspectProspects p249
The Howard Hughes Medical Institute has unveiled a programme to offer start-up funds for young biomedical scientists.
Paul Smaglik
doi:10.1038/nj7184-249a
Career View
Daniel Kelly, scientific director, Burnham Institute for Medical Research, Orlando, Florida p250
Science director appointed to Burnham Institute's new Florida location.
Virginia Gewin
doi:10.1038/nj7184-250a
Sunny view for Florida life sciences p250
Florida adds to growing collection of high-profile institutes.
Virginia Gewin
doi:10.1038/nj7184-250b
David versus Goliath p250
It can be a battleground in the lab.
Zachary Lippman
doi:10.1038/nj7184-250c