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Brief Communication Arising

Nature 452, E1 (6 March 2008) | doi:10.1038/nature06574; Received 4 September 2007; Accepted 29 November 2007

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Arousal by stimulation of deep-brain nuclei

Hugh Staunton1

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Arising from: N. D. Schiff et al. Nature 448, 600–603 (2007); Schiff et al. reply

Schiff et al.1 show that deep-brain stimulation of the unspecific thalamocortical system through certain midline thalamic nuclei produces an alerting effect in a patient in a minimally conscious state. Such nuclei include the central lateral nucleus, paralaminar regions of the median dorsalis, and the posterior–medial aspect of the centromedian/parafascicularis nucleus complex.