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Nature 452, 38-39 (6 March 2008) | doi:10.1038/452038a; Published online 5 March 2008

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Neuroscience: A complex in psychosis

Solomon H. Snyder1

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The molecular basis of psychoses such as schizophrenia remains largely mysterious. The interaction between two of the brain receptors involved adds to evidence that will help in the search for explanations.

This is a story that involves three types of receptor in the brain that influence human perception and behaviour (those for the neurotransmitters dopamine, serotonin and glutamate), and the drugs that block or enhance their activity. Such drugs are used by researchers to investigate the causes of psychotic disorders such as schizophrenia, and by clinicians to treat patients.

  1. Solomon H. Snyder is in the Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-2185, USA.
    Email: ssnyder@jhmi.edu

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