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Review
Nature 451, 1069-1075 (28 February 2008) | doi:10.1038/nature06639
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Postdoctoral Associate in Enzyme Biochemistry
- Cornell University
- Ithaca, NY
Tenure-track Faculty Positions
- University of Michigan
- Ann Arbor, Michigan, USA
Autophagy fights disease through cellular self-digestion
Noboru Mizushima1, Beth Levine2, Ana Maria Cuervo3 & Daniel J. Klionsky4
Abstract
Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.
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