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Nature 451, 1065-1066 (28 February 2008) | doi:10.1038/4511065a; Published online 27 February 2008
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History of science: Quinine steps back in time
Philip Ball1
Abstract
Chemists have long memories. The claim, dating back to 1918, that a crucial step in a synthesis of quinine had been carried out has been validated experimentally, closing a chapter in this fascinating story.
"One of the greatest scientific achievements in a century" was how The New York Times hailed the 'total synthesis' of quinine reported in 1944 by Robert Woodward and William Doering at Harvard University1, 2. But had they really achieved it at all?
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