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Nature 451, 943-948 (21 February 2008) | doi:10.1038/nature06801; Published online 20 February 2008
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Review Article The developmental genetics of congenital heart disease
Benoit G. Bruneau1
Abstract
Congenital heart disease is the leading cause of infant morbidity in the Western world, but only in the past ten years has its aetiology been understood. Recent studies have uncovered the genetic basis for some common forms of the disease and provide new insight into how the heart develops and how dysregulation of heart development leads to disease.
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