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Nature 451, 644-647 (7 February 2008) | doi:10.1038/451644a; Published online 6 February 2008

Open Innovation Challenges

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A systematic look at an old problem

Thomas B. L. Kirkwood1

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As life expectancy increases, a systems-biology approach is needed to ensure that we have a healthy old age.

The continuing increase in life expectancy, which in many countries advances by several hours per day, is one of humanity's most astonishing successes. But as the population ages, new approaches are required to unravel the complex biology of ageing and understand its links with frailty and disease.

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