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Nature 451, 596-599 (31 January 2008) | doi:10.1038/nature06528;
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Assistant / Associate Professor
- Yale University
- New Haven, CT
Postdoctoral Position
- Fox Chase Cancer Center
- Philadelphia, Pennsylvania, United States, 19111
Structural basis for the function and inhibition of an influenza virus proton channel
The M2 protein from influenza A virus is a pH-activated proton channel that mediates acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the anti-influenza drugs amantadine and rimantadine; recently, resistance to these drugs in humans, birds and pigs has reached more than 90% (ref.
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