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Nature 451, 330-334 (17 January 2008) | doi:10.1038/nature06493;
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Reversal of pathological pain through specific spinal GABAA receptor subtypes
Inflammatory diseases and neuropathic insults are frequently accompanied by severe and debilitating pain, which can become chronic and often unresponsive to conventional analgesic treatment. A loss of synaptic inhibition in the spinal dorsal horn is considered to contribute significantly to this pain pathology.
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