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Nature 451, 254-255 (17 January 2008) | doi:10.1038/451254a; Published online 16 January 2008
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Immunology: Cascade into clarity
Fayyaz S. Sutterwala1 & Richard A. Flavell2
Abstract
Immune mediator molecules such as antimicrobial peptides are crucial for host responses to pathogens. Akirins are the latest identified components of a signalling cascade that leads to these responses in insects and mice.
The availability of powerful genetic tools to study the fruitfly Drosophila melanogaster, and the striking similarities of this insect's immune system to that of mammals, makes Drosophila a valuable organism for researchers interested in innate (nonspecific) immune responses. Indeed, among other advances, the discovery of Toll-like receptors, which are essential mediators of innate immunity in mammals, came about through studies in Drosophila.
- Fayyaz S. Sutterwala is in the Department of Medicine, Inflammation Program, University of Iowa, Iowa City, Iowa 52241, USA.
Email: fayyaz-sutterwala@uiowa.edu - Richard A. Flavell is in the Department of Immunobiology and the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Email: richard.flavell@yale.edu
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