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Immunology

Cascade into clarity

Immune mediator molecules such as antimicrobial peptides are crucial for host responses to pathogens. Akirins are the latest identified components of a signalling cascade that leads to these responses in insects and mice.

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Figure 1: Role of Akirin proteins in producing immune mediators following microbial infection.

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Sutterwala, F., Flavell, R. Cascade into clarity. Nature 451, 254–255 (2008). https://doi.org/10.1038/451254a

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