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Nature 451, 252-253 (17 January 2008) | doi:10.1038/451252a; Published online 16 January 2008
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Academic Dermatopathologist
- Brighsm and Women's Hospital
- Boston, MA
Lectureship in Ecology
- University of Southampton
- Southampton, Hampshire, SO16 7PX, UK
Cancer: Hay in a haystack
Kevin M. Shannon1 & Michelle M. Le Beau2
Abstract
Although some diseases occur when both copies of a gene are mutated, mutation of just one copy of certain tumour-suppressor genes promotes tumorigenesis. Identifying such mutations is arduous, but worth the effort.
The myelodysplastic syndromes are thought to result from mutations in haematopoietic stem cells that result in the inefficient production of blood cells. Anaemia is a frequent manifestation, and patients often become dependent on red-blood-cell transfusions.
- Kevin M. Shannon is in the Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0519, USA.
Email: shannonk@peds.ucsf.edu - Michelle M. Le Beau is in the Section of Hematology/Oncology and the Cancer Research Center, University of Chicago, 5841 South Maryland Avenue, MC2115, Chicago, Illinois 60637, USA.
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RESEARCH
Identification of RPS14 as a 5q - syndrome gene by RNA interference screenNature Letters to Editor (17 Jan 2008)
