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Nature 451, 135-136 (10 January 2008) | doi:10.1038/451135a; Published online 9 January 2008
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Postdoctoral Research Fellows
- Northwestern University
- Chicago, Illinois, United States
Paleobiologist / Biogeochemist
- University of Cincinnati
- Cincinnati, Ohio, USA
Stem cells: A new year and a new era
Martin F. Pera1
Abstract
Manipulating cells from adult human tissue, scientists have generated cells with the same developmental potential as embryonic stem cells. The research opportunities these exciting observations offer are limitless.
In 2006, a groundbreaking study1 showed that when adult mouse skin cells are manipulated to transiently express four transcription factors (Oct4, Sox2, Kfl4 and Myc), they can become reprogrammed — that is, transformed back to the equivalent of an early embryonic state, as occurs during the cloning of animals from adult cells. Four studies, including one on page 141 of this issue by Park et al.2, now show that the introduction and expression of the same transcription factors2, 3 or a slightly modified combination of them4, 5 can also trigger the reprogramming of differentiated human cells.
- Martin F. Pera is at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Email: pera@usc.edu
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