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Nature 451, 131-132 (10 January 2008) | doi:10.1038/451131a; Published online 9 January 2008

Molecular biology: RNA rules

Meng-Chao Yao1

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Studies of an old genetic puzzle in a little-known protozoan reveal a new frontier in the expanding world of RNAs: an RNA template guides genome-wide DNA rearrangements during sexual reproduction.

Ciliated protozoa are unicellular organisms the analysis of which — largely because of the unusual organization of their genome — has led to fascinating fundamental discoveries, such as those of telomeres and catalytic RNAs. These protozoa contain both a germline nucleus and a somatic (non-germline) nucleus.

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