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Brief Communication Arising
Nature 450, E23 (20 December 2007) | doi:10.1038/nature06437; Received 3 January 2007; Accepted 17 October 2007
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Stem cell treatment of dystrophic dogs
Allan H. Bretag1
Abstract
Arising from: M. Sampaolesi et al. Nature 444, 574–579 (2006); Sampaolesi et al. reply
Human muscular dystrophies are devastating and incurable inherited diseases. Hopes of progress towards therapy of muscular dystrophies were aroused when Sampaolesi et al.1 reported "extensive recovery of dystrophin expression, normal muscle...function", and "remarkable clinical amelioration" in golden retriever muscular dystrophy dogs treated with 'mesoangioblasts'. Here I re-examine their results, showing how their assessments might be flawed and their conclusions overstated. Further studies will be required to evaluate fully the clinical potential of this work.
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