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From the following article:

Nanog safeguards pluripotency and mediates germline development

Ian Chambers, Jose Silva, Douglas Colby, Jennifer Nichols, Bianca Nijmeijer, Morag Robertson, Jan Vrana, Ken Jones, Lars Grotewold & Austin Smith

Nature 450, 1230-1234(20 December 2007)

doi:10.1038/nature06403

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Nanog expression within the undifferentiated embryonic stem-cell population is reversible.

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Figure 2

Nanog-/- embryonic stem cells retain expression of pluripotency markers and the capacity for in vitro self renewal.

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Figure 3

Nanog-/- cells retain the potential for embryo colonization and somatic contribution to chimaeras.

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Figure 4

Nanog is required for cell state transitions during germ cell development and for cell state reversions in embryonic stem-cell cultures.

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