Figures and Tables

From the following article:

Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

James A. Wells & Christopher L. McClendon

Nature 450, 1001-1009(13 December 2007)

doi:10.1038/nature06526

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Figure 1

Examples of protein–protein interface hotspots.

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Figure 2

Examples of small molecules that inhibit protein–protein interactions.

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Figure 3

Four comparisons of how a protein interacts with its natural protein (or peptide) partner and with a synthetic small molecule.

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Figure 4

Disruption of TNF by a small molecule.

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Figure 5

Relationship between compound potency and size for small molecules that inhibit protein–protein interactions.

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Table 1

Comparison of protein and small-molecule binding partners

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Table 2

Ligand efficiencies of other small molecules that inhibit protein–protein interactions

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