FIGURE 4. eCM engraftment improves conduction and prevents re-entry in Langendorff-perfused hearts.
From the following article:
Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
Wilhelm Roell, Thorsten Lewalter, Philipp Sasse, Yvonne N. Tallini, Bum-Rak Choi, Martin Breitbach, Robert Doran, Ulrich M. Becher, Seong-Min Hwang, Toktam Bostani, Julia von Maltzahn, Andreas Hofmann, Shaun Reining, Britta Eiberger, Bethann Gabris, Alexander Pfeifer, Armin Welz, Klaus Willecke, Guy Salama, Jan W. Schrickel, Michael I. Kotlikoff & Bernd K. Fleischmann
Nature 450, 819-824(6 December 2007)
doi:10.1038/nature06321
a, Sequential images from a series showing the first derivative (2-ms interval) of action-potential propagation during pacing. The infarct region is outlined by a black circle. b, Representative isochronal maps depicting the activation wavefront and conduction delays near the infarct border zone. The activation bypasses the sham-injected infarct (upper left), or initiates from an ectopic focus at the border zone (right), whereas it proceeds through the eCM-injected lesion (lower left). Scale bar indicates local activation times. c, Local conduction velocities. There is a more than fourfold increase within eCM-engrafted infarcts (P < 0.001; numbers above bars indicate n; error bars show s.e.m.). d, Sequential di-4-ANNEPS fluorescence images show induction of spiral waves in a sham-injected heart (images cropped around infarct zone). The infarct region is ringed in the leftmost panel.
