TY - JOUR AU - Palade, G. TI - Intracellular aspects of the process of protein synthesis JA - Science PY - 1975/// VL - 189 SP - 347 EP - 358 PB - Nature Publishing Group M3 - 10.1126/science.1096303 N1 - 10.1126/science.1096303 UR - http://dx.doi.org/10.1126/science.1096303 ER - TY - JOUR AU - Blobel, G. AU - Sabatini, D. D. TI - Ribosome-membrane interaction in eukaryotic cells JA - Biomembranes PY - 1971/// VL - 2 SP - 193 EP - 195 PB - Nature Publishing Group ER - TY - JOUR AU - Milstein, C. AU - Brownlee, G. G. AU - Harrison, T. M. AU - Mathews, M. B. TI - A possible precursor of immunoglobulin light chains JA - Nature New Biol. PY - 1972/// VL - 239 SP - 117 EP - 120 PB - Nature Publishing Group M3 - 10.1038/239117a0 N1 - 10.1038/239117a0 UR - http://dx.doi.org/10.1038/239117a0 ER - TY - JOUR AU - Inouye, H. AU - Beckwith, J. TI - Synthesis and processing of an Escherichia coli alkaline phosphatase precursor in vitro JA - Proc. Natl Acad. Sci. USA PY - 1977/// VL - 74 SP - 1440 EP - 1444 PB - Nature Publishing Group M3 - 10.1073/pnas.74.4.1440 N1 - 10.1073/pnas.74.4.1440 UR - http://dx.doi.org/10.1073/pnas.74.4.1440 ER - TY - JOUR AU - Halegoua, S. AU - Sekizawa, J. AU - Inouye, M. TI - A new form of structural lipoprotein of outer membrane of Escherichia coli JA - J. Biol. Chem. PY - 1977/// VL - 252 SP - 2324 EP - 2330 PB - Nature Publishing Group ER - TY - JOUR AU - Emr, S. D. AU - Hanley-Way, S. AU - Silhavy, T. TI - Suppressor mutations that restore export of a protein with a defective signal sequence JA - Cell PY - 1981/// VL - 23 SP - 79 EP - 88 PB - Nature Publishing Group M3 - 10.1016/0092-8674(81)90272-5 N1 - 10.1016/0092-8674(81)90272-5 UR - http://dx.doi.org/10.1016/0092-8674(81)90272-5 ER - TY - JOUR AU - Oliver, D. B. AU - Beckwith, J. E. TI - coli mutant pleiotropically defective in the export of secreted proteins JA - Cell PY - 1981/// VL - 25 SP - 765 EP - 772 PB - Nature Publishing Group M3 - 10.1016/0092-8674(81)90184-7 N1 - 10.1016/0092-8674(81)90184-7 UR - http://dx.doi.org/10.1016/0092-8674(81)90184-7 ER - TY - JOUR AU - Deshaies, R. J. AU - Schekman, R. TI - A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum JA - J. Cell Biol. PY - 1987/// VL - 105 SP - 633 EP - 645 PB - Nature Publishing Group M3 - 10.1083/jcb.105.2.633 N1 - 10.1083/jcb.105.2.633 UR - http://dx.doi.org/10.1083/jcb.105.2.633 ER - TY - JOUR AU - Blobel, G. AU - Dobberstein, B. TI - Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components JA - J. Cell Biol. PY - 1975/// VL - 67 SP - 852 EP - 862 PB - Nature Publishing Group M3 - 10.1083/jcb.67.3.852 N1 - 10.1083/jcb.67.3.852 UR - http://dx.doi.org/10.1083/jcb.67.3.852 ER - TY - JOUR AU - Van den Berg, B. TI - X-ray structure of a protein-conducting channel JA - Nature PY - 2004/// VL - 427 SP - 36 EP - 44 PB - Nature Publishing Group M3 - 10.1038/nature02218 N1 - 10.1038/nature02218 UR - http://dx.doi.org/10.1038/nature02218 ER - TY - JOUR AU - Osborne, A. R. AU - Rapoport, T. A. AU - van den Berg, B. TI - Protein translocation by the Sec61/SecY channel JA - Annu. Rev. Cell Dev. Biol. PY - 2005/// VL - 21 SP - 529 EP - 550 PB - Nature Publishing Group M3 - 10.1146/annurev.cellbio.21.012704.133214 N1 - 10.1146/annurev.cellbio.21.012704.133214 UR - http://dx.doi.org/10.1146/annurev.cellbio.21.012704.133214 ER - TY - JOUR AU - Mothes, W. AU - Prehn, S. AU - Rapoport, T. A. TI - Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane JA - EMBO J. PY - 1994/// VL - 13 SP - 3937 EP - 3982 PB - Nature Publishing Group ER - TY - JOUR AU - Akimaru, J. AU - Matsuyama, S. AU - Tokuda, H. AU - Mizushima, S. TI - Reconstitution of a protein translocation system containing purified SecY, SecE, and SecA from Escherichia coli JA - Proc. Natl Acad. Sci. USA PY - 1991/// VL - 88 SP - 6545 EP - 6549 PB - Nature Publishing Group M3 - 10.1073/pnas.88.15.6545 N1 - 10.1073/pnas.88.15.6545 UR - http://dx.doi.org/10.1073/pnas.88.15.6545 ER - TY - JOUR AU - Brundage, L. AU - Hendrick, J. P. AU - Schiebel, E. AU - Driessen, A. J. AU - Wickner, W. TI - The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation JA - Cell PY - 1990/// VL - 62 SP - 649 EP - 657 PB - Nature Publishing Group M3 - 10.1016/0092-8674(90)90111-Q N1 - 10.1016/0092-8674(90)90111-Q UR - http://dx.doi.org/10.1016/0092-8674(90)90111-Q ER - TY - JOUR AU - Gorlich, D. AU - Rapoport, T. A. TI - Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane JA - Cell PY - 1993/// VL - 75 SP - 615 EP - 630 PB - Nature Publishing Group M3 - 10.1016/0092-8674(93)90483-7 N1 - 10.1016/0092-8674(93)90483-7 UR - http://dx.doi.org/10.1016/0092-8674(93)90483-7 ER - TY - JOUR AU - Simon, S. M. AU - Blobel, G. TI - A protein-conducting channel in the endoplasmic reticulum JA - Cell PY - 1991/// VL - 65 SP - 371 EP - 380 PB - Nature Publishing Group M3 - 10.1016/0092-8674(91)90455-8 N1 - 10.1016/0092-8674(91)90455-8 UR - http://dx.doi.org/10.1016/0092-8674(91)90455-8 ER - TY - JOUR AU - Crowley, K. S. AU - Reinhart, G. D. AU - Johnson, A. E. TI - The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation JA - Cell PY - 1993/// VL - 73 SP - 1101 EP - 1115 PB - Nature Publishing Group M3 - 10.1016/0092-8674(93)90640-C N1 - 10.1016/0092-8674(93)90640-C UR - http://dx.doi.org/10.1016/0092-8674(93)90640-C ER - TY - JOUR AU - Crowley, K. S. AU - Liao, S. R. AU - Worrell, V. E. AU - Reinhart, G. D. AU - Johnson, A. E. TI - Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore JA - Cell PY - 1994/// VL - 78 SP - 461 EP - 471 PB - Nature Publishing Group M3 - 10.1016/0092-8674(94)90424-3 N1 - 10.1016/0092-8674(94)90424-3 UR - http://dx.doi.org/10.1016/0092-8674(94)90424-3 ER - TY - JOUR AU - Breyton, C. AU - Haase, W. AU - Rapoport, T. A. AU - Kuhlbrandt, W. AU - Collinson, I. TI - Three-dimensional structure of the bacterial protein-translocation complex SecYEG JA - Nature PY - 2002/// VL - 418 SP - 662 EP - 665 PB - Nature Publishing Group M3 - 10.1038/nature00827 N1 - 10.1038/nature00827 UR - http://dx.doi.org/10.1038/nature00827 ER - TY - JOUR AU - Bostina, M. AU - Mohsin, B. AU - Kuhlbrandt, W. AU - Collinson, I. TI - Atomic model of the E. coli membrane-bound protein translocation complex SecYEG JA - J. Mol. Biol. PY - 2005/// VL - 352 SP - 1035 EP - 1043 PB - Nature Publishing Group M3 - 10.1016/j.jmb.2005.08.005 N1 - 10.1016/j.jmb.2005.08.005 UR - http://dx.doi.org/10.1016/j.jmb.2005.08.005 ER - TY - JOUR AU - Luirink, J. AU - Sinning, I. TI - SRP-mediated protein targeting: structure and function revisited JA - Biochim. Biophys. Acta PY - 2004/// VL - 1694 SP - 17 EP - 35 PB - Nature Publishing Group ER - TY - JOUR AU - Halic, M. AU - Beckmann, R. TI - The signal recognition particle and its interactions during protein targeting JA - Curr. Opin. Struct. Biol. PY - 2005/// VL - 15 SP - 116 EP - 125 PB - Nature Publishing Group M3 - 10.1016/j.sbi.2005.01.013 N1 - 10.1016/j.sbi.2005.01.013 UR - http://dx.doi.org/10.1016/j.sbi.2005.01.013 ER - TY - JOUR AU - Connolly, T. AU - Gilmore, R. TI - Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein JA - J. Cell Biol. PY - 1986/// VL - 103 SP - 2253 EP - 2261 PB - Nature Publishing Group M3 - 10.1083/jcb.103.6.2253 N1 - 10.1083/jcb.103.6.2253 UR - http://dx.doi.org/10.1083/jcb.103.6.2253 ER - TY - JOUR AU - Mothes, W. TI - Molecular mechanism of membrane protein integration into the endoplasmic reticulum JA - Cell PY - 1997/// VL - 89 SP - 523 EP - 533 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)80234-2 N1 - 10.1016/S0092-8674(00)80234-2 UR - http://dx.doi.org/10.1016/S0092-8674(00)80234-2 ER - TY - JOUR AU - Ng, D. T. AU - Brown, J. D. AU - Walter, P. TI - Signal sequences specify the targeting route to the endoplasmic reticulum membrane JA - J. Cell Biol. PY - 1996/// VL - 134 SP - 269 EP - 278 PB - Nature Publishing Group M3 - 10.1083/jcb.134.2.269 N1 - 10.1083/jcb.134.2.269 UR - http://dx.doi.org/10.1083/jcb.134.2.269 ER - TY - JOUR AU - Huber, D. TI - Use of thioredoxin as a reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition particle-dependent translocation JA - J. Bacteriol. PY - 2005/// VL - 187 SP - 2983 EP - 2991 PB - Nature Publishing Group M3 - 10.1128/JB.187.9.2983-2991.2005 N1 - 10.1128/JB.187.9.2983-2991.2005 UR - http://dx.doi.org/10.1128/JB.187.9.2983-2991.2005 ER - TY - JOUR AU - Huber, D. TI - A selection for mutants that interfere with folding of Escherichia coli thioredoxin-1 in vivo JA - Proc. Natl Acad. Sci. USA PY - 2005/// VL - 102 SP - 18872 EP - 18877 PB - Nature Publishing Group M3 - 10.1073/pnas.0509583102 N1 - 10.1073/pnas.0509583102 UR - http://dx.doi.org/10.1073/pnas.0509583102 ER - TY - JOUR AU - Deshaies, R. J. AU - Sanders, S. L. AU - Feldheim, D. A. AU - Schekman, R. TI - Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex JA - Nature PY - 1991/// VL - 349 SP - 806 EP - 808 PB - Nature Publishing Group M3 - 10.1038/349806a0 N1 - 10.1038/349806a0 UR - http://dx.doi.org/10.1038/349806a0 ER - TY - JOUR AU - Panzner, S. AU - Dreier, L. AU - Hartmann, E. AU - Kostka, S. AU - Rapoport, T. A. TI - Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p JA - Cell PY - 1995/// VL - 81 SP - 561 EP - 570 PB - Nature Publishing Group M3 - 10.1016/0092-8674(95)90077-2 N1 - 10.1016/0092-8674(95)90077-2 UR - http://dx.doi.org/10.1016/0092-8674(95)90077-2 ER - TY - JOUR AU - Meyer, H. A. TI - Mammalian Sec61 is associated with Sec62 and Sec63 JA - J. Biol. Chem. PY - 2000/// VL - 275 SP - 14550 EP - 14557 PB - Nature Publishing Group M3 - 10.1074/jbc.275.19.14550 N1 - 10.1074/jbc.275.19.14550 UR - http://dx.doi.org/10.1074/jbc.275.19.14550 ER - TY - JOUR AU - Tyedmers, J. TI - Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes JA - Proc. Natl Acad. Sci. USA PY - 2000/// VL - 97 SP - 7214 EP - 7219 PB - Nature Publishing Group M3 - 10.1073/pnas.97.13.7214 N1 - 10.1073/pnas.97.13.7214 UR - http://dx.doi.org/10.1073/pnas.97.13.7214 ER - TY - JOUR AU - Plath, K. AU - Rapoport, T. A. TI - Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum JA - J. Cell Biol. PY - 2000/// VL - 151 SP - 167 EP - 178 PB - Nature Publishing Group M3 - 10.1083/jcb.151.1.167 N1 - 10.1083/jcb.151.1.167 UR - http://dx.doi.org/10.1083/jcb.151.1.167 ER - TY - JOUR AU - Matlack, K. E. AU - Misselwitz, B. AU - Plath, K. AU - Rapoport, T. A. TI - BiP acts as a molecular ratchet during posttranslational transport of prepro-[agr] factor across the ER membrane JA - Cell PY - 1999/// VL - 97 SP - 553 EP - 564 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)80767-9 N1 - 10.1016/S0092-8674(00)80767-9 UR - http://dx.doi.org/10.1016/S0092-8674(00)80767-9 ER - TY - JOUR AU - Misselwitz, B. AU - Staeck, O. AU - Rapoport, T. A. TI - J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences JA - Mol. Cell PY - 1998/// VL - 2 SP - 593 EP - 603 PB - Nature Publishing Group M3 - 10.1016/S1097-2765(00)80158-6 N1 - 10.1016/S1097-2765(00)80158-6 UR - http://dx.doi.org/10.1016/S1097-2765(00)80158-6 ER - TY - JOUR AU - Hunt, J. F. TI - Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA JA - Science PY - 2002/// VL - 297 SP - 2018 EP - 2026 PB - Nature Publishing Group M3 - 10.1126/science.1074424 N1 - 10.1126/science.1074424 UR - http://dx.doi.org/10.1126/science.1074424 ER - TY - JOUR AU - Osborne, A. R. AU - Clemons, W. M. AU - Rapoport, T. A. TI - A large conformational change of the translocation ATPase SecA JA - Proc. Natl Acad. Sci. USA PY - 2004/// VL - 101 SP - 10937 EP - 10942 PB - Nature Publishing Group M3 - 10.1073/pnas.0401742101 N1 - 10.1073/pnas.0401742101 UR - http://dx.doi.org/10.1073/pnas.0401742101 ER - TY - JOUR AU - Or, E. AU - Navon, A. AU - Rapoport, T. TI - Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane JA - EMBO J. PY - 2002/// VL - 21 SP - 4470 EP - 4479 PB - Nature Publishing Group M3 - 10.1093/emboj/cdf471 N1 - 10.1093/emboj/cdf471 UR - http://dx.doi.org/10.1093/emboj/cdf471 ER - TY - JOUR AU - Duong, F. TI - Binding, activation and dissociation of the dimeric SecA ATPase at the dimeric SecYEG translocase JA - EMBO J. PY - 2003/// VL - 22 SP - 4375 EP - 4384 PB - Nature Publishing Group M3 - 10.1093/emboj/cdg418 N1 - 10.1093/emboj/cdg418 UR - http://dx.doi.org/10.1093/emboj/cdg418 ER - TY - JOUR AU - Or, E. AU - Boyd, D. AU - Gon, S. AU - Beckwith, J. AU - Rapoport, T. TI - The bacterial ATPase SecA functions as a monomer in protein translocation JA - J. Biol. Chem. PY - 2004/// VL - 280 SP - 9097 EP - 9105 PB - Nature Publishing Group M3 - 10.1074/jbc.M413947200 N1 - 10.1074/jbc.M413947200 UR - http://dx.doi.org/10.1074/jbc.M413947200 ER - TY - JOUR AU - Alami, M. AU - Dalal, K. AU - Lelj-Garolla, B. AU - Sligar, S. G. AU - Duong, F. TI - Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA JA - EMBO J. PY - 2007/// VL - 26 SP - 1995 EP - 2004 PB - Nature Publishing Group M3 - 10.1038/sj.emboj.7601661 N1 - 10.1038/sj.emboj.7601661 UR - http://dx.doi.org/10.1038/sj.emboj.7601661 ER - TY - JOUR AU - Jilaveanu, L. B. AU - Zito, C. R. AU - Oliver, D. TI - Dimeric SecA is essential for protein translocation JA - Proc. Natl Acad. Sci. USA PY - 2005/// VL - 102 SP - 7511 EP - 7516 PB - Nature Publishing Group M3 - 10.1073/pnas.0502774102 N1 - 10.1073/pnas.0502774102 UR - http://dx.doi.org/10.1073/pnas.0502774102 ER - TY - JOUR AU - de Keyzer, J. TI - Covalently dimerized SecA is functional in protein translocation JA - J. Biol. Chem. PY - 2005/// VL - 280 SP - 35255 EP - 35260 PB - Nature Publishing Group M3 - 10.1074/jbc.M506157200 N1 - 10.1074/jbc.M506157200 UR - http://dx.doi.org/10.1074/jbc.M506157200 ER - TY - JOUR AU - Mitra, K. AU - Frank, J. AU - Driessen, A. TI - Co- and post-translational translocation through the protein-conducting channel: analogous mechanisms at work? JA - Nature Struct. Mol. Biol. PY - 2006/// VL - 13 SP - 957 EP - 964 PB - Nature Publishing Group M3 - 10.1038/nsmb1166 N1 - 10.1038/nsmb1166 UR - http://dx.doi.org/10.1038/nsmb1166 ER - TY - JOUR AU - Randall, L. L. TI - Binding of SecB to ribosome-bound polypeptides has the same characteristics as binding to full-length, denatured proteins JA - Proc. Natl Acad. Sci. USA PY - 1997/// VL - 94 SP - 802 EP - 807 PB - Nature Publishing Group M3 - 10.1073/pnas.94.3.802 N1 - 10.1073/pnas.94.3.802 UR - http://dx.doi.org/10.1073/pnas.94.3.802 ER - TY - JOUR AU - Lill, R. AU - Dowhan, W. AU - Wickner, W. TI - The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins JA - Cell PY - 1990/// VL - 60 SP - 271 EP - 280 PB - Nature Publishing Group M3 - 10.1016/0092-8674(90)90742-W N1 - 10.1016/0092-8674(90)90742-W UR - http://dx.doi.org/10.1016/0092-8674(90)90742-W ER - TY - JOUR AU - Randall, L. L. AU - Hardy, S. J. TI - SecB, one small chaperone in the complex milieu of the cell JA - Cell. Mol. Life Sci. PY - 2002/// VL - 59 SP - 1617 EP - 1623 PB - Nature Publishing Group M3 - 10.1007/PL00012488 N1 - 10.1007/PL00012488 UR - http://dx.doi.org/10.1007/PL00012488 ER - TY - JOUR AU - Musial-Siwek, M. AU - Rusch, S. L. AU - Kendall, D. A. TI - Selective photoaffinity labeling identifies the signal peptide binding domain on SecA JA - J. Mol. Biol. PY - 2006/// VL - 365 SP - 637 EP - 648 PB - Nature Publishing Group M3 - 10.1016/j.jmb.2006.10.027 N1 - 10.1016/j.jmb.2006.10.027 UR - http://dx.doi.org/10.1016/j.jmb.2006.10.027 ER - TY - JOUR AU - Osborne, A. R. AU - Rapoport, T. A. TI - Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel JA - Cell PY - 2007/// VL - 129 SP - 97 EP - 110 PB - Nature Publishing Group M3 - 10.1016/j.cell.2007.02.036 N1 - 10.1016/j.cell.2007.02.036 UR - http://dx.doi.org/10.1016/j.cell.2007.02.036 ER - TY - JOUR AU - Economou, A. AU - Wickner, W. TI - SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion JA - Cell PY - 1994/// VL - 78 SP - 835 EP - 843 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(94)90582-7 N1 - 10.1016/S0092-8674(94)90582-7 UR - http://dx.doi.org/10.1016/S0092-8674(94)90582-7 ER - TY - JOUR AU - Rajapandi, T. AU - Oliver, D. TI - SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state JA - Cell PY - 1994/// VL - 78 SP - 845 EP - 853 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(94)90602-5 N1 - 10.1016/S0092-8674(94)90602-5 UR - http://dx.doi.org/10.1016/S0092-8674(94)90602-5 ER - TY - JOUR AU - Schiebel, E. AU - Driessen, A. J. AU - Hartl, F. U. AU - Wickner, W. TI - [Dgr][mgr]H+ and ATP function at different steps of the catalytic cycle of preprotein translocase JA - Cell PY - 1991/// VL - 64 SP - 927 EP - 939 PB - Nature Publishing Group M3 - 10.1016/0092-8674(91)90317-R N1 - 10.1016/0092-8674(91)90317-R UR - http://dx.doi.org/10.1016/0092-8674(91)90317-R ER - TY - JOUR AU - Irihimovitch, V. AU - Eichler, J. TI - Post-translational secretion of fusion proteins in the halophilic archaea Haloferax volcanii JA - J. Biol. Chem. PY - 2003/// VL - 278 SP - 12881 EP - 12887 PB - Nature Publishing Group M3 - 10.1074/jbc.M210762200 N1 - 10.1074/jbc.M210762200 UR - http://dx.doi.org/10.1074/jbc.M210762200 ER - TY - JOUR AU - Ortenberg, R. AU - Mevarech, M. TI - Evidence for post-translational membrane insertion of the integral membrane protein bacterioopsin expressed in the heterologous halophilic archaeon Haloferax volcanii JA - J. Biol. Chem. PY - 2000/// VL - 275 SP - 22839 EP - 22846 PB - Nature Publishing Group M3 - 10.1074/jbc.M908916199 N1 - 10.1074/jbc.M908916199 UR - http://dx.doi.org/10.1074/jbc.M908916199 ER - TY - JOUR AU - Shaw, A. S. AU - Rottier, P. J. AU - Rose, J. K. TI - Evidence for the loop model of signal-sequence insertion into the endoplasmic reticulum JA - Proc. Natl Acad. Sci. USA PY - 1988/// VL - 85 SP - 7592 EP - 7596 PB - Nature Publishing Group M3 - 10.1073/pnas.85.20.7592 N1 - 10.1073/pnas.85.20.7592 UR - http://dx.doi.org/10.1073/pnas.85.20.7592 ER - TY - JOUR AU - Raden, D. AU - Song, W. AU - Gilmore, R. TI - Role of the cytoplasmic segments of Sec61[agr] in the ribosome-binding and translocation-promoting activities of the Sec61 complex JA - J. Cell Biol. PY - 2000/// VL - 150 SP - 53 EP - 64 PB - Nature Publishing Group M3 - 10.1083/jcb.150.1.53 N1 - 10.1083/jcb.150.1.53 UR - http://dx.doi.org/10.1083/jcb.150.1.53 ER - TY - JOUR AU - Plath, K. AU - Mothes, W. AU - Wilkinson, B. M. AU - Stirling, C. J. AU - Rapoport, T. A. TI - Signal sequence recognition in posttranslational protein transport across the yeast ER membrane JA - Cell PY - 1998/// VL - 94 SP - 795 EP - 807 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)81738-9 N1 - 10.1016/S0092-8674(00)81738-9 UR - http://dx.doi.org/10.1016/S0092-8674(00)81738-9 ER - TY - JOUR AU - Harris, C. R. AU - Silhavy, T. J. TI - Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking JA - J. Bacteriol. PY - 1999/// VL - 181 SP - 3438 EP - 3444 PB - Nature Publishing Group ER - TY - JOUR AU - Tam, P. C. AU - Maillard, A. P. AU - Chan, K. K. AU - Duong, F. TI - Investigating the SecY plug movement at the SecYEG translocation channel JA - EMBO J. PY - 2005/// VL - 24 SP - 3380 EP - 3388 PB - Nature Publishing Group M3 - 10.1038/sj.emboj.7600804 N1 - 10.1038/sj.emboj.7600804 UR - http://dx.doi.org/10.1038/sj.emboj.7600804 ER - TY - JOUR AU - Smith, M. A. AU - Clemons, W. M. AU - DeMars, C. J. AU - Flower, A. M. TI - Modeling the effects of prl mutations on the Escherichia coli SecY complex JA - J. Bacteriol. PY - 2005/// VL - 187 SP - 6454 EP - 6465 PB - Nature Publishing Group M3 - 10.1128/JB.187.18.6454-6465.2005 N1 - 10.1128/JB.187.18.6454-6465.2005 UR - http://dx.doi.org/10.1128/JB.187.18.6454-6465.2005 ER - TY - JOUR AU - Weihofen, A. AU - Binns, K. AU - Lemberg, M. K. AU - Ashman, K. AU - Martoglio, B. TI - Identification of signal peptide peptidase, a presenilin-type aspartic protease JA - Science PY - 2002/// VL - 296 SP - 2215 EP - 2218 PB - Nature Publishing Group M3 - 10.1126/SCIENCE.1070925 N1 - 10.1126/SCIENCE.1070925 UR - http://dx.doi.org/10.1126/SCIENCE.1070925 ER - TY - JOUR AU - Cannon, K. S. AU - Or, E. AU - Clemons, W. M. AU - Shibata, Y. AU - Rapoport, T. A. TI - Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY JA - J. Cell Biol. PY - 2005/// VL - 169 SP - 219 EP - 225 PB - Nature Publishing Group M3 - 10.1083/jcb.200412019 N1 - 10.1083/jcb.200412019 UR - http://dx.doi.org/10.1083/jcb.200412019 ER - TY - JOUR AU - Tani, K. AU - Tokuda, H. AU - Mizushima, S. TI - Translocation of proOmpA possessing an intramolecular disulfide bridge into membrane vesicles of Escherichia coli. Effect of membrane energization JA - J. Biol. Chem. PY - 1990/// VL - 265 SP - 17341 EP - 17347 PB - Nature Publishing Group ER - TY - JOUR AU - Kurzchalia, T. V. TI - tRNA-mediated labelling of proteins with biotin. A nonradioactive method for the detection of cell-free translation products JA - Eur. J. Biochem. PY - 1988/// VL - 172 SP - 663 EP - 668 PB - Nature Publishing Group M3 - 10.1111/j.1432-1033.1988.tb13940.x N1 - 10.1111/j.1432-1033.1988.tb13940.x UR - http://dx.doi.org/10.1111/j.1432-1033.1988.tb13940.x ER - TY - JOUR AU - Gumbart, J. AU - Schulten, K. TI - Molecular dynamics studies of the archaeal translocon JA - Biophys. J. PY - 2006/// VL - 90 SP - 2356 EP - 2367 PB - Nature Publishing Group M3 - 10.1529/biophysj.105.075291 N1 - 10.1529/biophysj.105.075291 UR - http://dx.doi.org/10.1529/biophysj.105.075291 ER - TY - JOUR AU - Tian, P. AU - Andricioaei, I. TI - Size, motion, and function of the SecY translocon revealed by molecular dynamics simulations with virtual probes JA - Biophys. J. PY - 2006/// VL - 90 SP - 2718 EP - 2730 PB - Nature Publishing Group M3 - 10.1529/biophysj.105.073304 N1 - 10.1529/biophysj.105.073304 UR - http://dx.doi.org/10.1529/biophysj.105.073304 ER - TY - JOUR AU - Haider, S. AU - Hall, B. A. AU - Sansom, M. S. TI - Simulations of a protein translocation pore: SecY JA - Biochemistry PY - 2006/// VL - 45 SP - 13018 EP - 13024 PB - Nature Publishing Group M3 - 10.1021/bi061013d N1 - 10.1021/bi061013d UR - http://dx.doi.org/10.1021/bi061013d ER - TY - JOUR AU - Saparov, S. M. TI - Determining the conductance of the SecY protein translocation channel for small molecules JA - Mol. Cell PY - 2007/// VL - 26 SP - 501 EP - 509 PB - Nature Publishing Group M3 - 10.1016/j.molcel.2007.03.022 N1 - 10.1016/j.molcel.2007.03.022 UR - http://dx.doi.org/10.1016/j.molcel.2007.03.022 ER - TY - JOUR AU - Kowarik, M. AU - Kung, S. AU - Martoglio, B. AU - Helenius, A. TI - Protein folding during cotranslational translocation in the endoplasmic reticulum JA - Mol. Cell PY - 2002/// VL - 10 SP - 769 EP - 778 PB - Nature Publishing Group M3 - 10.1016/S1097-2765(02)00685-8 N1 - 10.1016/S1097-2765(02)00685-8 UR - http://dx.doi.org/10.1016/S1097-2765(02)00685-8 ER - TY - JOUR AU - Hamman, B. D. AU - Chen, J. C. AU - Johnson, E. E. AU - Johnson, A. E. TI - The aqueous pore through the translocon has a diameter of 40-60[thinsp]A during cotranslational protein translocation at the ER membrane JA - Cell PY - 1997/// VL - 89 SP - 535 EP - 544 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)80235-4 N1 - 10.1016/S0092-8674(00)80235-4 UR - http://dx.doi.org/10.1016/S0092-8674(00)80235-4 ER - TY - JOUR AU - Kaufmann, A. AU - Manting, E. H. AU - Veenendaal, A. K. AU - Driessen, A. J. AU - van der Does, C. TI - Cysteine-directed cross-linking demonstrates that helix 3 of SecE is close to helix 2 of SecY and helix 3 of a neighboring SecE JA - Biochemistry PY - 1999/// VL - 38 SP - 9115 EP - 9125 PB - Nature Publishing Group M3 - 10.1021/bi990539d N1 - 10.1021/bi990539d UR - http://dx.doi.org/10.1021/bi990539d ER - TY - JOUR AU - Mitra, K. TI - Structure of the E. coli protein-conducting channel bound to a translating ribosome JA - Nature PY - 2005/// VL - 438 SP - 318 EP - 324 PB - Nature Publishing Group M3 - 10.1038/nature04133 N1 - 10.1038/nature04133 UR - http://dx.doi.org/10.1038/nature04133 ER - TY - JOUR AU - Menetret, J. F. TI - Ribosome binding of a single copy of the SecY complex: implications for protein translocation JA - Mol. Cell PB - Nature Publishing Group ER - TY - JOUR AU - Voss, N. R. AU - Gerstein, M. AU - Steitz, T. A. AU - Moore, P. B. TI - The geometry of the ribosomal polypeptide exit tunnel JA - J. Mol. Biol. PY - 2006/// VL - 360 SP - 893 EP - 906 PB - Nature Publishing Group M3 - 10.1016/j.jmb.2006.05.023 N1 - 10.1016/j.jmb.2006.05.023 UR - http://dx.doi.org/10.1016/j.jmb.2006.05.023 ER - TY - JOUR AU - Halic, M. TI - Following the signal sequence from ribosomal tunnel exit to signal recognition particle JA - Nature PY - 2006/// VL - 444 SP - 507 EP - 511 PB - Nature Publishing Group M3 - 10.1038/nature05326 N1 - 10.1038/nature05326 UR - http://dx.doi.org/10.1038/nature05326 ER - TY - JOUR AU - Mitra, K. TI - Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements JA - Mol. Cell PY - 2006/// VL - 22 SP - 533 EP - 543 PB - Nature Publishing Group M3 - 10.1016/j.molcel.2006.05.003 N1 - 10.1016/j.molcel.2006.05.003 UR - http://dx.doi.org/10.1016/j.molcel.2006.05.003 ER - TY - JOUR AU - Johnson, A. E. TI - Maintaining the permeability barrier during protein trafficking at the endoplasmic reticulum membrane JA - Biochem. Soc. Trans. PY - 2003/// VL - 31 SP - 1227 EP - 1231 PB - Nature Publishing Group ER - TY - JOUR AU - Halic, M. TI - Signal recognition particle receptor exposes the ribosomal translocon binding site JA - Science PY - 2006/// VL - 312 SP - 745 EP - 747 PB - Nature Publishing Group M3 - 10.1126/science.1124864 N1 - 10.1126/science.1124864 UR - http://dx.doi.org/10.1126/science.1124864 ER - TY - JOUR AU - Schaletzky, J. AU - Rapoport, T. A. TI - Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane JA - Mol. Biol. Cell PY - 2006/// VL - 17 SP - 3860 EP - 3869 PB - Nature Publishing Group M3 - 10.1091/mbc.E06-05-0439 N1 - 10.1091/mbc.E06-05-0439 UR - http://dx.doi.org/10.1091/mbc.E06-05-0439 ER - TY - JOUR AU - Hanein, D. TI - Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation JA - Cell PY - 1996/// VL - 87 SP - 721 EP - 732 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)81391-4 N1 - 10.1016/S0092-8674(00)81391-4 UR - http://dx.doi.org/10.1016/S0092-8674(00)81391-4 ER - TY - JOUR AU - Beckmann, R. TI - Architecture of the protein-conducting channel associated with the translating 80S ribosome JA - Cell PY - 2001/// VL - 107 SP - 361 EP - 372 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(01)00541-4 N1 - 10.1016/S0092-8674(01)00541-4 UR - http://dx.doi.org/10.1016/S0092-8674(01)00541-4 ER - TY - JOUR AU - Menetret, J. F. TI - Architecture of the ribosome-channel complex derived from native membranes JA - J. Mol. Biol. PY - 2005/// VL - 348 SP - 445 EP - 457 PB - Nature Publishing Group M3 - 10.1016/j.jmb.2005.02.053 N1 - 10.1016/j.jmb.2005.02.053 UR - http://dx.doi.org/10.1016/j.jmb.2005.02.053 ER - TY - JOUR AU - Thanassi, D. G. AU - Stathopoulos, C. AU - Karkal, A. AU - Li, H. TI - Protein secretion in the absence of ATP: the autotransporter, two-partner secretion and chaperone/usher pathways of Gram-negative bacteria JA - Mol. Membr. Biol. PY - 2005/// VL - 22 SP - 63 EP - 72 PB - Nature Publishing Group M3 - 10.1080/09687860500063290 N1 - 10.1080/09687860500063290 UR - http://dx.doi.org/10.1080/09687860500063290 ER - TY - JOUR AU - Ahting, U. TI - The TOM core complex: the general protein import pore of the outer membrane of mitochondria JA - J. Cell Biol. PY - 1999/// VL - 147 SP - 959 EP - 968 PB - Nature Publishing Group M3 - 10.1083/jcb.147.5.959 N1 - 10.1083/jcb.147.5.959 UR - http://dx.doi.org/10.1083/jcb.147.5.959 ER - TY - JOUR AU - Rehling, P. TI - Protein insertion into the mitochondrial inner membrane by a twin-pore translocase JA - Science PY - 2003/// VL - 299 SP - 1747 EP - 1751 PB - Nature Publishing Group M3 - 10.1126/science.1080945 N1 - 10.1126/science.1080945 UR - http://dx.doi.org/10.1126/science.1080945 ER - TY - JOUR AU - Heinrich, S. U. AU - Mothes, W. AU - Brunner, J. AU - Rapoport, T. A. TI - The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain JA - Cell PY - 2000/// VL - 102 SP - 233 EP - 244 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)00028-3 N1 - 10.1016/S0092-8674(00)00028-3 UR - http://dx.doi.org/10.1016/S0092-8674(00)00028-3 ER - TY - JOUR AU - Hessa, T. TI - Recognition of transmembrane helices by the endoplasmic reticulum translocon JA - Nature PY - 2005/// VL - 433 SP - 377 EP - 381 PB - Nature Publishing Group M3 - 10.1038/nature03216 N1 - 10.1038/nature03216 UR - http://dx.doi.org/10.1038/nature03216 ER - TY - JOUR AU - Gumbart, J. AU - Schulten, K. TI - Structural determinants of lateral gate opening in the protein translocon JA - Biochemistry PY - 2007/// VL - 46 SP - 11147 EP - 11157 PB - Nature Publishing Group M3 - 10.1021/bi700835d N1 - 10.1021/bi700835d UR - http://dx.doi.org/10.1021/bi700835d ER - TY - JOUR AU - Wessels, H. P. AU - Spiess, M. TI - Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence JA - Cell PY - 1988/// VL - 55 SP - 61 EP - 70 PB - Nature Publishing Group M3 - 10.1016/0092-8674(88)90009-8 N1 - 10.1016/0092-8674(88)90009-8 UR - http://dx.doi.org/10.1016/0092-8674(88)90009-8 ER - TY - JOUR AU - Rapoport, T. A. AU - Goder, V. AU - Heinrich, S. U. AU - Matlack, K. E. TI - Membrane-protein integration and the role of the translocation channel JA - Trends Cell Biol. PY - 2004/// VL - 14 SP - 568 EP - 575 PB - Nature Publishing Group M3 - 10.1016/j.tcb.2004.09.002 N1 - 10.1016/j.tcb.2004.09.002 UR - http://dx.doi.org/10.1016/j.tcb.2004.09.002 ER - TY - JOUR AU - Le Gall, S. AU - Neuhof, A. AU - Rapoport, T. TI - The endoplasmic reticulum membrane is permeable to small molecules JA - Mol. Biol. Cell PY - 2004/// VL - 15 SP - 447 EP - 455 PB - Nature Publishing Group M3 - 10.1091/mbc.E03-05-0325 N1 - 10.1091/mbc.E03-05-0325 UR - http://dx.doi.org/10.1091/mbc.E03-05-0325 ER - TY - JOUR AU - Hamman, B. D. AU - Hendershot, L. M. AU - Johnson, A. E. TI - BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation JA - Cell PY - 1998/// VL - 92 SP - 747 EP - 758 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)81403-8 N1 - 10.1016/S0092-8674(00)81403-8 UR - http://dx.doi.org/10.1016/S0092-8674(00)81403-8 ER - TY - JOUR AU - Liao, S. AU - Lin, J. AU - Do, H. AU - Johnson, A. E. TI - Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration JA - Cell PY - 1997/// VL - 90 SP - 31 EP - 41 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)80311-6 N1 - 10.1016/S0092-8674(00)80311-6 UR - http://dx.doi.org/10.1016/S0092-8674(00)80311-6 ER - TY - JOUR AU - Woolhead, C. A. AU - McCormick, P. J. AU - Johnson, A. E. TI - Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins JA - Cell PY - 2004/// VL - 116 SP - 725 EP - 736 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(04)00169-2 N1 - 10.1016/S0092-8674(04)00169-2 UR - http://dx.doi.org/10.1016/S0092-8674(04)00169-2 ER - TY - JOUR AU - Lu, J. AU - Deutsch, C. TI - Secondary structure formation of a transmembrane segment in Kv channels JA - Biochemistry PY - 2005/// VL - 44 SP - 8230 EP - 8243 PB - Nature Publishing Group M3 - 10.1021/bi050372q N1 - 10.1021/bi050372q UR - http://dx.doi.org/10.1021/bi050372q ER - TY - JOUR AU - Menetret, J. F. TI - The structure of ribosome-channel complexes engaged in protein translocation JA - Mol. Cell PY - 2000/// VL - 6 SP - 1219 EP - 1232 PB - Nature Publishing Group M3 - 10.1016/S1097-2765(00)00118-0 N1 - 10.1016/S1097-2765(00)00118-0 UR - http://dx.doi.org/10.1016/S1097-2765(00)00118-0 ER - TY - JOUR AU - Schiebel, E. AU - Wickner, W. TI - Preprotein translocation creates a halide anion permeability in the Escherichia coli plasma membrane JA - J. Biol. Chem. PY - 1992/// VL - 267 SP - 7505 EP - 7510 PB - Nature Publishing Group ER - TY - JOUR AU - Junne, T. AU - Schwede, T. AU - Goder, V. AU - Spiess, M. TI - The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability JA - Mol. Biol. Cell PY - 2006/// VL - 17 SP - 4063 EP - 4068 PB - Nature Publishing Group M3 - 10.1091/mbc.E06-03-0200 N1 - 10.1091/mbc.E06-03-0200 UR - http://dx.doi.org/10.1091/mbc.E06-03-0200 ER - TY - JOUR AU - Maillard, A. P. AU - Lalani, S. AU - Silva, F. AU - Belin, D. AU - Duong, F. TI - Deregulation of the SecYEG translocation channel upon removal of the plug domain JA - J. Biol. Chem. PY - 2007/// VL - 282 SP - 1281 EP - 1287 PB - Nature Publishing Group M3 - 10.1074/jbc.M610060200 N1 - 10.1074/jbc.M610060200 UR - http://dx.doi.org/10.1074/jbc.M610060200 ER - TY - JOUR AU - Li, W. TI - The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal JA - Mol. Cell PY - 2007/// VL - 26 SP - 511 EP - 521 PB - Nature Publishing Group M3 - 10.1016/j.molcel.2007.05.002 N1 - 10.1016/j.molcel.2007.05.002 UR - http://dx.doi.org/10.1016/j.molcel.2007.05.002 ER -