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Editorials

The heat is on p319

At December's climate-change meeting, everyone can agree on one thing: it is make-or-break time.

doi:10.1038/450319a


Enhancing, not cheating p320

A broad debate about the use of drugs that improve cognition for both the healthy and the ill is needed.

doi:10.1038/450320a


Prescription for change p320

Health research in Italy is in desperate need of a fresh start.

doi:10.1038/450320b


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Research Highlights

Research highlights p322

doi:10.1038/450322a


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Journal Club

Journal club p323

Clive R. Bagshaw

doi:10.1038/450323a


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News

Pakistan's universities take up protest p324

Scientists demonstrate against state of emergency.

Ehsan Masood

doi:10.1038/450324a


Merck settles Vioxx lawsuits for $4.85 billion p324

But drug firm maintains it was not at fault over arthritis drug.

Meredith Wadman

doi:10.1038/450324b


HIV vaccine may raise risk p325

Infection rates increase in some trial participants.

Heidi Ledford

doi:10.1038/450325a


The price of power p326

The price of oil is hovering at around US$100 a barrel, a psychologically powerful level that experts and analysts once discussed in purely theoretical terms. John Deutch, a chemistry professor at the Massachusetts Institute of Technology in Cambridge and former director of the US Central Intelligence Agency under President Clinton, gives his thoughts on the issue.

Jeff Tollefson

doi:10.1038/450326a


Graphic detail Countries with highest CO2-emitting power sectors (Tonnes per year) p327

World's most CO2 emitting power stations revealed.

Jeff Tollefson

doi:10.1038/450327a


Panel negotiates climate 'synthesis report' p327

IPCC summarizes science data in 100 pages for policy-makers.

Jeff Tollefson

doi:10.1038/450327b


Snapshot: Light relief p329

Jellyfish add a touch of glass to the ceiling.

Nick Thomas

doi:10.1038/450329a


Brain waves reveal intensity of pain p329

Neural signal offers objective measure of subjective experience.

Kerri Smith

doi:10.1038/450329b


Light wormholes could wire space invisibly p330

Invisible channels offer optical collusion.

Philip Ball

doi:10.1038/450330a


Sidelines p331

Scribbles on the margins of science.

doi:10.1038/450331a


New Jersey rebuffs loan to fund stem-cell research p332

doi:10.1038/450332a


Accelerator will bring antiproton beam online p332

doi:10.1038/450332b


Knowledge gaps pour cold water on sea fertilization p332

doi:10.1038/450332c


Patient privacy rules hamper US research p332

doi:10.1038/450332d


Cap on overheads may put universities off defence p332

doi:10.1038/450332e


Lunar pole captured on Moon video p332

doi:10.1038/450332f


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Correction

Correction p332

doi:10.1038/450332g


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Column

Party of One

Political climate p333

American legislators are getting started on the first laws to tackle greenhouse-gas emissions. But Congress has a long way to go, says David Goldston.

David Goldston

doi:10.1038/450333a


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Business

Worth its weight in platinum p334

Booming mineral prices leave car makers scrambling to eke more catalytic performance out of precious metals. Jeff Tollefson reports.

Jeff Tollefson

doi:10.1038/450334a


Pullback from proteins p335

doi:10.1038/450335a


Tag team p335

doi:10.1038/450335b


Flu drug fall p335

doi:10.1038/450335c


Market watch p335

Quirin Schiermeier

doi:10.1038/450335d


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News Features

Climate politics: Showdown in a sunburnt country p336

Climate is shaping up as an issue in the 24 November Australian elections, as Stephen Pincock reports.

doi:10.1038/450336a


Climate politics: Beyond Bush p340

The next US president could lead the country into meaningful action on controlling greenhousegas emissions, but only if he, or she, can seize the moment. Jeff Tollefson reports.

doi:10.1038/450340a


Climate politics: The first cut p342

For the first time, the US Congress has begun crafting comprehensive legislation to tackle global warming. Nature brought together five experts with various backgrounds to discuss the current political climate as the United States moves towards mandatory emissions caps.

doi:10.1038/450342a


Climate politics: What every president should know p345

If you want to lead the free world, you'd better know your physics. That's the lesson from a popular undergraduate class, called 'Physics for future presidents', taught by Richard A. Muller at the University of California, Berkeley. Here he sets some typical questions. An interactive version of this quiz with extended answers is online at http://www.nature.com/news/specials/climatepolitics/index.html.

doi:10.1038/450345a


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Correspondence

Independent evidence backs call for a badger cull p346

David King

doi:10.1038/450346a


Kyoto: talks must include key aspects of science p346

Aynsley Kellow

doi:10.1038/450346b


Kyoto: no time to rearrange deckchairs on the Titanic p346

John Schellnhuber

doi:10.1038/450346c


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Commentary

Who has the ear of the president? p347

50 years after the appointment of the first presidential science adviser, the White House is flooded with scientific information. Roger Pielke Jr suggests how the next administration might develop ways to use it best.

doi:10.1038/450347a

See also: Editor's summary


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Books and Arts

A sixth mass extinction? p349

Past species losses have much to teach us about current and future declines due to human activity.

Chris D. Thomas reviews Terra: Our 100-Million-Year-Old Ecosystem — and the Threats that Now Put it at Risk by Michael Novacek

doi:10.1038/450349a


Prescient marine champion p350

Ken Collins reviews The Human, the Orchid and the Octopus: Exploring and Conserving our Natural World by Jacques Cousteau & Susan Schiefelbein

doi:10.1038/450350a


Human distilleries p350

Robert P. Crease reviews Rethinking Expertise by Harry Collins & Robert Evans

doi:10.1038/450350b


Blurring our edges p351

Judy Illes reviews Enhancing Evolution: The Ethical Case for Making Better People by John Harris and Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime by Aubrey de Grey & Michael Rae

doi:10.1038/450351a


Archimedes' secrets revealed p352

Brian Clegg reviews The Archimedes Codex by Reviel Netz & William Noel

doi:10.1038/450352a


Exhibition: The liquid of life p353

Josie Glausiusz reviews Water: H2O=Life

doi:10.1038/450353a


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Essay

Science & politics

Use the calm between the storms p354

To save lives and livelihoods, natural and social scientists must work with decision-makers and politicians in the time between natural disasters as well as during them.

Steve Sparks

doi:10.1038/450354a

See also: Editor's summary


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News and Views

Structural biology: A receptor unlocked p355

G-protein-coupled receptors govern many biological functions, yet little is known about the molecular basis of their activity. The structure of a prominent example of these receptors is now revealed.

Stephen R. Sprang

doi:10.1038/450355a

See also: Editor's summary


Planetary science: Isotopic lunacy p356

The Moon could have been derived from a well-mixed disk of rock vapour that was produced after the early Earth collided with another planet. This persuasive idea offers a fresh perspective on the history of both bodies.

Alex N. Halliday

doi:10.1038/450356a


Epigenetics: Reversing the 'irreversible' p357

"Do not speak — unless it improves on silence" is generally wise advice, and is even vital for a subset of essential genes. New studies describe how, when appropriate, the silence of these genes is broken.

Richard S. Jones

doi:10.1038/450357a


Carbon cycle: Quick burial at sea p360

The amount of river-borne carbon that is buried upon reaching the sea affects Earth's atmospheric composition. A study of rivers draining the Himalaya shows that carbon burial may occur more efficiently than was thought.

Caroline A. Masiello

doi:10.1038/450360a


Microbiology: Pathogen drop-kick p361

To set the scene for its replication, the bacterium Legionella pneumophila exploits its host cells' Rab1 protein. This pathogen seems to use minimal resources to mimic the normal cycle of Rab1 activity.

Suzanne Pfeffer

doi:10.1038/450361a

See also: Editor's summary


50 & 100 Years Ago p362

doi:10.1038/450362a


Quantum optics: Kittens catch phase p362

The most sensitive phase-measuring instrument yet uses quantum trickery and a scaled-down version of the notorious Schrödinger's cat. It means that more sensitive devices for metrology and imaging could be on the way.

Jonathan P. Dowling

doi:10.1038/450362b

See also: Editor's summary


Clarification p363

doi:10.1038/450363a


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Brief Communications Arising

Anti-correlation of summer/winter monsoons? pE7

De'er Zhang & Longhua Lu

doi:10.1038/nature06338


Yancheva et al. reply pE8

Gergana Yancheva, Norbert R. Nowaczyk, Jens Mingram, Peter Dulski, Georg Schettler, Jörg F. W. Negendank, Jiaqi Liu, Daniel M. Sigman, Larry C. Peterson & Gerald H. Haug

doi:10.1038/nature06339


Record of winter monsoon strength pE10

Houyun Zhou, Huazheng Guan & Baoquan Chi

doi:10.1038/nature06408


Yancheva et al. reply pE11

Gergana Yancheva, Norbert R. Nowaczyk, Jens Mingram, Peter Dulski, Georg Schettler, Jörg F. W. Negendank, Jiaqi Liu, Daniel M. Sigman, Larry C. Peterson & Gerald H. Haug

doi:10.1038/nature06409


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Articles

Legionella pneumophila proteins that regulate Rab1 membrane cycling p365

Alyssa Ingmundson, Anna Delprato, David G. Lambright & Craig R. Roy

doi:10.1038/nature06336

See also: Editor's summary | News and Views by Pfeffer


Portability of paddle motif function and pharmacology in voltage sensors p370

AbdulRasheed A. Alabi, Maria Isabel Bahamonde, Hoi Jong Jung, Jae Il Kim & Kenton J. Swartz

doi:10.1038/nature06266

See also: Editor's summary


Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment p376

Stephen B. Long, Xiao Tao, Ernest B. Campbell & Roderick MacKinnon

doi:10.1038/nature06265

See also: Editor's summary


Crystal structure of the human beta2 adrenergic G-protein-coupled receptor p383

Søren G. F. Rasmussen, Hee-Jung Choi, Daniel M. Rosenbaum, Tong Sun Kobilka, Foon Sun Thian, Patricia C. Edwards, Manfred Burghammer, Venkata R. P. Ratnala, Ruslan Sanishvili, Robert F. Fischetti, Gebhard F. X. Schertler, William I. Weis & Brian K. Kobilka

doi:10.1038/nature06325

See also: Editor's summary | News and Views by Sprang


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Letters

A runaway collision in a young star cluster as the origin of the brightest supernova p388

Simon F. Portegies Zwart & Edward P. J. van den Heuvel

doi:10.1038/nature06276

See also: Editor's summary


Pulsational pair instability as an explanation for the most luminous supernovae p390

S. E. Woosley, S. Blinnikov & Alexander Heger

doi:10.1038/nature06333

See also: Editor's summary


Entanglement-free Heisenberg-limited phase estimation p393

B. L. Higgins, D. W. Berry, S. D. Bartlett, H. M. Wiseman & G. J. Pryde

doi:10.1038/nature06257

See also: Editor's summary | News and Views by Dowling


'Trapped rainbow' storage of light in metamaterials p397

Kosmas L. Tsakmakidis, Allan D. Boardman & Ortwin Hess

doi:10.1038/nature06285

See also: Editor's summary


Generation of single optical plasmons in metallic nanowires coupled to quantum dots p402

A. V. Akimov, A. Mukherjee, C. L. Yu, D. E. Chang, A. S. Zibrov, P. R. Hemmer, H. Park & M. D. Lukin

doi:10.1038/nature06230


Efficient organic carbon burial in the Bengal fan sustained by the Himalayan erosional system p407

Valier Galy, Christian France-Lanord, Olivier Beyssac, Pierre Faure, Hermann Kudrass & Fabien Palhol

doi:10.1038/nature06273

See also: News and Views by Masiello


Cooperation and conflict in quorum-sensing bacterial populations p411

Stephen P. Diggle, Ashleigh S. Griffin, Genevieve S. Campbell & Stuart A. West

doi:10.1038/nature06279

See also: Editor's summary


SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron p415

Kristen Jepsen, Derek Solum, Tianyuan Zhou, Robert J. McEvilly, Hyun-Jung Kim, Christopher K. Glass, Ola Hermanson & Michael G. Rosenfeld

doi:10.1038/nature06270

See also: News and Views by Jones


Neural substrates of awakening probed with optogenetic control of hypocretin neurons p420

Antoine R. Adamantidis, Feng Zhang, Alexander M. Aravanis, Karl Deisseroth & Luis de Lecea

doi:10.1038/nature06310

See also: Editor's summary


A synaptic memory trace for cortical receptive field plasticity p425

Robert C. Froemke, Michael M. Merzenich & Christoph E. Schreiner

doi:10.1038/nature06289


BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module p430

Daeho Park, Annie-Carole Tosello-Trampont, Michael R. Elliott, Mingjian Lu, Lisa B. Haney, Zhong Ma, Alexander L. Klibanov, James W. Mandell & Kodi S. Ravichandran

doi:10.1038/nature06329

See also: Editor's summary


Identification of Tim4 as a phosphatidylserine receptor p435

Masanori Miyanishi, Kazutoshi Tada, Masato Koike, Yasuo Uchiyama, Toshio Kitamura & Shigekazu Nagata

doi:10.1038/nature06307

See also: Editor's summary


SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation p440

Alejandro Vaquero, Michael Scher, Hediye Erdjument-Bromage, Paul Tempst, Lourdes Serrano & Danny Reinberg

doi:10.1038/nature06268


Molecular basis of RNA-dependent RNA polymerase II activity p445

Elisabeth Lehmann, Florian Brueckner & Patrick Cramer

doi:10.1038/nature06290

See also: Editor's summary


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Corrigendum

Positive darwinian selection at the imprinted MEDEA locus in plants p450

Charles Spillane, Karl J. Schmid, Sylvia Laoueillé-Duprat, Stéphane Pien, Juan-Miguel Escobar-Restrepo, Célia Baroux, Valeria Gagliardini, Damian R. Page, Kenneth H. Wolfe & Ueli Grossniklaus

doi:10.1038/nature06439


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Naturejobs

Prospect

Prospects p451

Research parks are sprouting up all over North America. Is there a downside?

Gene Russo

doi:10.1038/nj7168-451a


Region

Allowing an élite p452

Dropping the dogma that all are equal is letting Germany's centres of excellence flourish. Quirin Schiermeier meets the new leaders.

Quirin Schiermeier

doi:10.1038/nj7168-452a


Highlights

Opportunities: The National Institutes of Health

doi:10.1038/nj0190


Spotlight

Spotlight on Germany

doi:10.1038/nj0191


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Futures

A better mousetrap p456

The appliance of science.

Mike Resnick

doi:10.1038/450456a


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