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News and Views
Nature 450, 361-362 (15 November 2007) | doi:10.1038/450361a; Published online 14 November 2007
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Microbiology: Pathogen drop-kick
Suzanne Pfeffer1
Abstract
To set the scene for its replication, the bacterium Legionella pneumophila exploits its host cells' Rab1 protein. This pathogen seems to use minimal resources to mimic the normal cycle of Rab1 activity.
The bacterium Legionella pneumophila is the main agent responsible for both Legionnaires' disease, which leads to pneumonia, and Pontiac fever, an illness that resembles acute influenza. This pathogen is engulfed by immune cells known as macrophages and, once inside, exploits proteins mediating intracellular trafficking to form an organelle called an L. pneumophila
- Suzanne Pfeffer is in the Department of Biochemistry, 279 Campus Drive, Room B400, Stanford University School of Medicine, Stanford, California 94305-5307, USA.
Email: pfeffer@stanford.edu
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