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Nature 450, 357-359 (15 November 2007) | doi:10.1038/450357a; Published online 14 November 2007
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Epigenetics: Reversing the 'irreversible'
Richard S. Jones1
Abstract
"Do not speak — unless it improves on silence" is generally wise advice, and is even vital for a subset of essential genes. New studies describe how, when appropriate, the silence of these genes is broken.
In cellular tissues, it is essential that certain genes are turned on in appropriate cells but remain silent in others. For years, the dogma has been that some forms of gene silencing are irreversible, or at least extremely stable.
- Richard S. Jones is in the Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75275-0376, USA.
Email: rjones@smu.edu
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