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From the following article:

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

Alejandro Vaquero, Michael Scher, Hediye Erdjument-Bromage, Paul Tempst, Lourdes Serrano & Danny Reinberg

Nature 450, 440-444(15 November 2007)

doi:10.1038/nature06268

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

The histone lysine methyltransferase SUV39H1 interacts with catalytically active SIRT1 in vitro and in vivo.

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Figure 2

SIRT1 upregulates SUV39H1 activity in vitro and in vivo through the SIRT1 N terminus.

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Figure 3

Acetylation of SUV39H1 negatively regulates its activity and is elevated in nicotinamide-treated cells.

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Figure 4

SIRT1 and SUV39H1 activities are linked in vivo.

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