Editorials

A drop in the ocean p135

Wave power and other renewable-energy resources deserve carefully targeted government support.

doi:10.1038/450135a

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The great divide p135

The gap between theory and practice remains surprisingly wide in conservation biology.

doi:10.1038/450135b

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Deadly consequences p136

Health authorities have yet to respond effectively to the combination of HIV and tuberculosis.

doi:10.1038/450136a

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Research Highlights

Research highlights p138

doi:10.1038/450138a

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Journal Club

Journal club p139

Brian J. Enquist

doi:10.1038/450139a

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News

Foreign students face extra UK security checks p140

Science graduates to be vetted before visa application.

Geoff Brumfiel

doi:10.1038/450140a

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Excessive fat intake can throw out the body clock p141

Dietary factors shown to influence sleep pattern.

Heidi Ledford

doi:10.1038/450141b

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Attack of the genomes p142

How many genome sequences do you need to characterize a model organism? For Drosophila, Heidi Ledford finds, a dozen is a good start.

Heidi Ledford

doi:10.1038/450142a

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Sidelines p144

doi:10.1038/450144a

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Poor follow-up hampers malaria projects p144

The money may be flowing, but is anyone watching whether it's well spent?

Declan Butler

doi:10.1038/450144b

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Committee releases shortlist of Mars landing sites p145

Experts worry practicality may win over science in final selection.

Oliver Morton

doi:10.1038/450145a

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Peering into the heart of a black hole p147

A glimpse beyond the event horizon.

Philip Ball

doi:10.1038/450147a

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Congress to vote on open access and NIH funds p148

doi:10.1038/450148a

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Argo system makes a splash with final float p148

doi:10.1038/450148b

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Biomedical agency puts epigenetics on the map p148

doi:10.1038/450148c

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Factory delay leaves flamingos in the pink p148

doi:10.1038/450148d

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San Francisco gets a green natural history museum p149

doi:10.1038/450149a

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Partnership paves way for global carbon market p149

doi:10.1038/450149b

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White males maintain pole positions in US science p149

doi:10.1038/450149c

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Correction

Correction p149

doi:10.1038/450149d

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Business

Carbon tax lite p151

The impact of a British tax on greenhouse-gas emissions has faded over time, as Geoff Brumfiel reports.

Geoff Brumfiel

doi:10.1038/450151a

Full Text | PDF (249K)

News Features

Conservation priorities: What to let go p152

Not all species can be saved from extinction. Emma Marris talks to conservation biologists about prioritization and triage.

doi:10.1038/450152a

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Energy: To catch a wave p156

Ocean wave energy is trying to break into the renewable-energy market, but many challenges remain. Ewen Callaway reports.

doi:10.1038/450156a

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Correspondence

Time: research necessities make it hard to keep track p161

Robert J. O'Connell

doi:10.1038/450161a

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Time: accounting problems caused by Caltech system p161

Robert D. McKeown

doi:10.1038/450161b

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Turkish science suffers as government vies with law p161

A. M. Celâl Sengör

doi:10.1038/450161c

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Explorers' challenge sunk by Arctic warming p161

A. J. (Tom) van Loon

doi:10.1038/450161d

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Commentaries

Rules of engagement p163

Is there an inherent conflict between public debate and free scientific inquiry? Patrick L. Taylor argues that earning public trust is essential to defending scientific freedoms.

doi:10.1038/450163a

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See also: Editor's summary

Benchmarks for ageing studies p165

The hopes for improving human health during ageing are largely based on studies with animal models. But Linda Partridge and David Gems ask if we are learning the right lessons from ageing research.

doi:10.1038/450165a

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Books and Arts

The twentieth century in a nutshell p169

A sad and salutary tale of success, commerce, hubris, razzmatazz and scientific heroism.

Colin Tudge reviews American Chestnut: The Life, Death, and Rebirth of a Perfect Tree by Susan Freinkel

doi:10.1038/450169a

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Television: Dover trial documentary screens p170

Adam Rutherford reviews Judgment Day: Intelligent Design on Trial

doi:10.1038/450170a

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Comparing modes of inquiry p171

Carlos Martínez del Rio reviews Science Without Laws: Model Systems, Cases, Exemplary Narratives

doi:10.1038/450171a

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Dance of the forest p172

Michael Hopkin reviews Biome choreographed by Jodi Lamask

doi:10.1038/450172a

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Exhibition: Demonic deeds in symbiotic art p172

Colin Martin reviews Little Savages

doi:10.1038/450172b

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Essays

Time to pick the fly's brain p173

Drosophila transformed developmental genetics and cell biology. Now the fruitfly is poised to help biologists decipher how the brain works.

Claude Desplan

doi:10.1038/450173a

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See also: Editor's summary

A timely harvest p174

The public should be consulted on contentious research and development early enough for their opinions to influence the course of science and policy-making.

Pierre-Benoit Joly & Arie Rip

doi:10.1038/450174a

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Correction

Correction p174

doi:10.1038/450174b

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News and Views

Quantum information: Reality check p175

It will be a long experimental haul before the great potential of quantum effects can routinely be exploited for technological ends. A sense of practical purpose among researchers will encourage progress.

Liesbeth Venema

doi:10.1038/450175a

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Computational biology: Protein predictions p176

Predicting the three-dimensional structure of a protein from its amino-acid sequence is a dauntingly complex task. But with colossal computer power and knowledge of other structures, it can be done.

Eleanor J. Dodson

doi:10.1038/nature05990

Full Text | PDF (226K)

Materials science: Magnetic blue p177

A commonly used blue dye is more than just a pretty colour. This material and its relatives are semiconductors, and their magnetic properties can be controlled by engineering their crystal structure.

Jeroen van den Brink & Alberto F. Morpurgo

doi:10.1038/450177a

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Planetary science: A twist on periodicity at Saturn p178

Saturn's nominal rotation period is timed by a 'radio clock' that counts bursts of emissions controlled by the planet's magnetic field. Buffeting by the solar wind may explain the clock's irregularities.

Margaret Galland Kivelson

doi:10.1038/450178a

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Fisheries: Nets versus nature p179

The life-histories of pike adjust quickly to shifts in the opposing forces of fishing and natural selection. Such rapid changes suggest that evolutionary dynamics must be incorporated into fisheries management.

David O. Conover

doi:10.1038/450179a

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Developmental biology: The power of blood p180

Compared with the masterpiece crafted by nature, even Leonardo da Vinci's anatomical drawings of the cardiovascular system seem primitive. In creating this system, nature seems to use blood flow as its paintbrush.

Paige Snider & Simon J. Conway

doi:10.1038/450180a

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50 & 100 Years Ago p181

doi:10.1038/450181a

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Obituary: Wolfgang K. H. Panofsky (1919–2007) p182

Physicist, and passionate and influential advocate of arms control.

Sidney D. Drell

doi:10.1038/450182a

Full Text | PDF (141K)

Brief Communications Arising

Maternal nodal and zebrafish embryogenesis pE1

James T. Bennett, Heather L. Stickney, Wen-Yee Choi, Brian Ciruna, William S. Talbot & Alexander F. Schier

doi:10.1038/nature06314

First paragraph | Full Text | PDF (819K)

Gore et al. reply pE2

Aniket V. Gore, Albert Cheong, Patrick C. Gilligan & Karuna Sampath

doi:10.1038/nature06315

First paragraph | Full Text | PDF (819K)

Evolution of animal personalities pE5

Richard McElreath, Barney Luttbeg, Sean P. Fogarty, Tomas Brodin & Andrew Sih

doi:10.1038/nature06326

First paragraph | Full Text | PDF (82K)

Wolf et al. reply pE5

Max Wolf, G. Sander van Doorn, Olof Leimar & Franz J. Weissing

doi:10.1038/nature06327

First paragraph | Full Text | PDF (82K)

Review

The remarkable metal-catalysed olefin metathesis reaction p243

Amir H. Hoveyda & Adil R. Zhugralin

doi:10.1038/nature06351

First paragraph | Full Text | PDF (476K)

See also: Editor's summary

Articles

Hedgehog regulates smoothened activity by inducing a conformational switch p252

Yun Zhao, Chao Tong & Jin Jiang

doi:10.1038/nature06225

Abstract | Full Text | PDF (905K) | Supplementary information

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High-resolution structure prediction and the crystallographic phase problem p259

Bin Qian, Srivatsan Raman, Rhiju Das, Philip Bradley, Airlie J. McCoy, Randy J. Read & David Baker

doi:10.1038/nature06249

Abstract | Full Text | PDF (1,773K) | Supplementary information

See also: Editor's summary | News and Views by Dodson

Letters

Modulation of Saturn's radio clock by solar wind speed p265

Philippe Zarka, Laurent Lamy, Baptiste Cecconi, Renée Prangé & Helmut O. Rucker

doi:10.1038/nature06237

First paragraph | Full Text | PDF (799K) | Supplementary information

See also: Editor's summary | News and Views by Kivelson

Cavity QED with a Bose–Einstein condensate p268

Ferdinand Brennecke, Tobias Donner, Stephan Ritter, Thomas Bourdel, Michael Köhl & Tilman Esslinger

doi:10.1038/nature06120

First paragraph | Full Text | PDF (437K)

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Strong atom–field coupling for Bose–Einstein condensates in an optical cavity on a chip p272

Yves Colombe, Tilo Steinmetz, Guilhem Dubois, Felix Linke, David Hunger & Jakob Reichel

doi:10.1038/nature06331

First paragraph | Full Text | PDF (776K) | Supplementary information

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Stability of organic carbon in deep soil layers controlled by fresh carbon supply p277

Sébastien Fontaine, Sébastien Barot, Pierre Barré, Nadia Bdioui, Bruno Mary & Cornelia Rumpel

doi:10.1038/nature06275

First paragraph | Full Text | PDF (257K) | Supplementary information

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Detection of stratospheric ozone intrusions by windprofiler radars p281

W. K. Hocking, T. Carey-Smith, D. W. Tarasick, P. S. Argall, K. Strong, Y. Rochon, I. Zawadzki & P. A. Taylor

doi:10.1038/nature06312

First paragraph | Full Text | PDF (675K) | Supplementary information

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Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch p285

Kenta Yashiro, Hidetaka Shiratori & Hiroshi Hamada

doi:10.1038/nature06254

First paragraph | Full Text | PDF (1,592K) | Supplementary information

See also: Editor's summary | News and Views by Snider & Conway

An essential role for a CD36-related receptor in pheromone detection in Drosophila p289

Richard Benton, Kirsten S. Vannice & Leslie B. Vosshall

doi:10.1038/nature06328

First paragraph | Full Text | PDF (931K) | Supplementary information

Drosophila hygrosensation requires the TRP channels water witch and nanchung p294

Lei Liu, Yuhong Li, Runping Wang, Chong Yin, Qian Dong, Huey Hing, Changsoo Kim & Michael J. Welsh

doi:10.1038/nature06223

First paragraph | Full Text | PDF (952K) | Supplementary information

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Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA p299

Di Yu, Andy Hee-Meng Tan, Xin Hu, Vicki Athanasopoulos, Nicholas Simpson, Diego G. Silva, Andreas Hutloff, Keith M. Giles, Peter J. Leedman, Kong Peng Lam, Christopher C. Goodnow & Carola G. Vinuesa

doi:10.1038/nature06253

First paragraph | Full Text | PDF (545K) | Supplementary information

An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster p304

Hang Yin & Haifan Lin

doi:10.1038/nature06263

First paragraph | Full Text | PDF (584K) | Supplementary information

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes p309

David Frescas, Daniele Guardavaccaro, Florian Bassermann, Ryo Koyama-Nasu & Michele Pagano

doi:10.1038/nature06255

First paragraph | Full Text | PDF (417K) | Supplementary information

See also: Editor's summary

Naturejobs

Prospects p315

These days, the more mobile the scientist, the better.

Gene Russo

doi:10.1038/nj7167-315a

Full Text | PDF (86K)

Alan Bernstein, executive director, Global HIV Vaccine Enterprise, Seattle, Washington p316

Physics student turned biomedical scientist becomes executive director of Global HIV Vaccine Enterprise

Virginia Gewin

doi:10.1038/nj7167-316a

Full Text | PDF (86K)

Latin American challenges p316

Young scientists in Latin America face special challenges despite progress.

Fernanda De Felice

doi:10.1038/nj7167-316b

Full Text | PDF (86K)

Meet my lab minion p316

Some day I'll have minions to do all those menial laboratory tasks for me. Some day...

Chris Rowan

doi:10.1038/nj7167-316c

Full Text | PDF (86K)

Highlight on The Netherlands

doi:10.1038/nj0188

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Futures

A hand and honour p318

Keeping pace with the human race.

Brenda Cooper

doi:10.1038/450318a

Full Text | PDF (103K)