FIGURE 1. Phylogeny and alignment of 12 Drosophila species.

From the following article:

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

Alexander Stark, Michael F. Lin, Pouya Kheradpour, Jakob S. Pedersen, Leopold Parts, Joseph W. Carlson, Madeline A. Crosby, Matthew D. Rasmussen, Sushmita Roy, Ameya N. Deoras, J. Graham Ruby, Julius Brennecke, Harvard FlyBase curators, Berkeley Drosophila Genome Project, Emily Hodges, Angie S. Hinrichs, Anat Caspi, Benedict Paten, Seung-Won Park, Mira V. Han, Morgan L. Maeder, Benjamin J. Polansky, Bryanne E. Robson, Stein Aerts, Jacques van Helden, Bassem Hassan, Donald G. Gilbert, Deborah A. Eastman, Michael Rice, Michael Weir, Matthew W. Hahn, Yongkyu Park, Colin N. Dewey, Lior Pachter, W. James Kent, David Haussler, Eric C. Lai, David P. Bartel, Gregory J. Hannon, Thomas C. Kaufman, Michael B. Eisen, Andrew G. Clark, Douglas Smith, Susan E. Celniker, William M. Gelbart, Manolis Kellis, Harvard FlyBase curators & Berkeley Drosophila Genome Project

Nature 450, 219-232(8 November 2007)



a, Phylogenetic tree relating the 12 Drosophila species, estimated from fourfold degenerate sites (Supplementary Methods 1). The 12 species span a total branch length of 4.13 substitutions per neutral site. b, Gene order conservation for a 0.45-Mb region of chromosome 2L centred on CG4495, for which we predict a new exon (Fig. 3a), and spanning 35 genes. Colour represents the direction of transcription. Boxes represent full gene models. Individual exons and introns are not shown. c, Comparison of evolutionary distances spanned by fly and vertebrate trees. Pairwise and multi-species distances (in substitutions per fourfold degenerate site) are shown from D. melanogaster and from human as reference genomes. Note that species with longer branches (for example, mouse) show higher pairwise distances, not always reflecting the order of divergence. Multi-species distances include all species within a phylogenetic clade.