Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Article
Nature 449, 919-922 (18 October 2007) | doi:10.1038/nature06205;
Open Innovation Challenges
-
Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
- More Challenges
- Powered by:
nature jobs
Sr. Scientific Manager / Chief Scientific Manager- Discovery Metabolism and Pharmacokinetics (MAP)
- Syngene International
- Bangalore, Karnataka 560099 India
Senior Lecturer / Lecturer in Filarial Parasitology
- LSTM
- Liverpool, United Kingdom
Interferon modulation of cellular microRNAs as an antiviral mechanism
RNA interference through non-coding microRNAs (miRNAs) represents a vital component of the innate antiviral immune response in plants and invertebrate animals; however, a role for cellular miRNAs in the defence against viral infection in mammalian organisms has thus far remained elusive. Here we show that interferon beta (IFN|[bgr]|) rapidly modulates the expression of numerous cellular miRNAs, and that eight of these IFN|[bgr]|-induced miRNAs have sequence-predicted targets within the hepatitis C virus (HCV) genomic RNA.
&
Abstract
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
