Figures and Tables
From the following article:
Helicobacter exploits integrin for type IV secretion and kinase activation
Terry Kwok, Dana Zabler, Sylwia Urman, Manfred Rohde, Roland Hartig, Silja Wessler, Rolf Misselwitz, Jürgen Berger, Norbert Sewald, Wolfgang König & Steffen Backert
Nature 449, 862-866(18 October 2007)
doi:10.1038/nature06187
Figure 1
Phosphorylated CagA co-localizes with focal adhesion proteins during infection with H. pylori, and integrin
1 is required for type-IV secretion of CagA into target cells.
Figure 2
The surface protein CagL associates with the type-IV secretion pilus surface during infection.
Full size figure and legend (337K)Figure 3
H. pylori CagL and its RGD motif are essential for type-IV secretion of CagA.
Full size figure and legend (268K)Figure 5
The RGD motif of CagL is crucial for activation of FAK and Src tyrosine kinases.
Full size figure and legend (103K)Figure 6
Three-step model for the activation of the H. pylori type-IV secretion system and phosphorylation of CagA through interaction of CagL with integrin.
Full size figure and legend (409K)




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