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From the following article:

Helicobacter exploits integrin for type IV secretion and kinase activation

Terry Kwok, Dana Zabler, Sylwia Urman, Manfred Rohde, Roland Hartig, Silja Wessler, Rolf Misselwitz, Jürgen Berger, Norbert Sewald, Wolfgang König & Steffen Backert

Nature 449, 862-866(18 October 2007)

doi:10.1038/nature06187

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Phosphorylated CagA co-localizes with focal adhesion proteins during infection with H. pylori, and integrin beta1 is required for type-IV secretion of CagA into target cells.

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Figure 2

The surface protein CagL associates with the type-IV secretion pilus surface during infection.

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Figure 3

H. pylori CagL and its RGD motif are essential for type-IV secretion of CagA.

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Figure 4

RGD-dependent interaction of CagL with integrin alpha5beta1.

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Figure 5

The RGD motif of CagL is crucial for activation of FAK and Src tyrosine kinases.

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Figure 6

Three-step model for the activation of the H. pylori type-IV secretion system and phosphorylation of CagA through interaction of CagL with integrin.

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