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Nature 449, 671-673 (11 October 2007) | doi:10.1038/449671a; Published online 10 October 2007

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Cancer: Micromanagement of metastasis

Patricia S. Steeg1

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Although they were discovered only in the early 1990s, many regulatory functions of microRNAs — naturally occurring short RNA sequences — have already been reported. The latest news is that they mediate cancer spread.

To successfully spread, or metastasize, a tumour cell must complete a complex set of processes, including invasion, survival and arrest in the circulatory system, and colonization of foreign organs1. How are these events regulated?

  1. Patricia S. Steeg is at the National Cancer Institute, Building 37, Room 1122, 37 Convent Drive, Bethesda, Maryland 20892, USA.
    Email: steegp@mail.nih.gov

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