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News and Views
Nature 449, 671-673 (11 October 2007) | doi:10.1038/449671a; Published online 10 October 2007
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Developer - Variation (Bioinformatician)
- European Bioinformatics Institute (EBI)
- Cambridge CB10 1SD United Kingdom
Chair
- McMaster University
- Hamilton, Canada
Cancer: Micromanagement of metastasis
Patricia S. Steeg1
Abstract
Although they were discovered only in the early 1990s, many regulatory functions of microRNAs — naturally occurring short RNA sequences — have already been reported. The latest news is that they mediate cancer spread.
To successfully spread, or metastasize, a tumour cell must complete a complex set of processes, including invasion, survival and arrest in the circulatory system, and colonization of foreign organs1. How are these events regulated?
- Patricia S. Steeg is at the National Cancer Institute, Building 37, Room 1122, 37 Convent Drive, Bethesda, Maryland 20892, USA.
Email: steegp@mail.nih.gov
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