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Nature 449, 667-669 (11 October 2007) | doi:10.1038/449667a; Published online 10 October 2007
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Cardiovascular Electrophysiologist / Pharmacologist - GlaxoSmithKline
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Organic chemistry: Zippier synthesis in water
Masayuki Inoue1
Abstract
Complex toxin molecules are the ultimate challenge for organic chemists — even successful syntheses often involve an impractical number of steps. A biologically inspired reaction might simplify things.
Nature creates many complex organic molecules, but some of the most spectacular are the brevetoxins and ciguatoxins produced by marine microorganisms1. Brevetoxins are the toxic component of dramatic natural phenomena known as red tides (Fig. 1
- Masayuki Inoue is at the Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Email: inoue@mol.f.u-tokyo.ac.jp
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