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Autoimmune disease

Skin deep but complex

Nature volume 449, pages 551–553 (2007)Cite this article

The antimicrobial peptide LL37 is essential for normal immune responses to infection or tissue injury. But in the autoimmune skin disorder psoriasis, LL37 propagates disease by forming complexes with host DNA.

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Figure 1: Role of LL37 in psoriasis.

Notes

  1. This article and the paper concerned1 were published online on 16 September 2007.

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Authors and Affiliations

  1. Nicole Baumgarth is in the Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, The Center for Comparative Medicine and Graduate Group in Immunology, University of California, Davis, 95616, California, USA

    Nicole Baumgarth

  2. Charles L. Bevins is in the Department of Microbiology and Immunology, School of Medicine, and Graduate Group in Immunology, University of California, Davis, California 95616, USA. clbevins@ucdavis.edu,

    Charles L. Bevins

Authors
  1. Nicole Baumgarth
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  2. Charles L. Bevins
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Baumgarth, N., Bevins, C. Skin deep but complex. Nature 449, 551–553 (2007). https://doi.org/10.1038/nature05893

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