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From the following article:

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Roberto Lande, Josh Gregorio, Valeria Facchinetti, Bithi Chatterjee, Yi-Hong Wang, Bernhard Homey, Wei Cao, Yui-Hsi Wang, Bing Su, Frank O. Nestle, Tomasz Zal, Ira Mellman, Jens-Michael Schröder, Yong-Jun Liu & Michel Gilliet

Nature 449, 564-569(4 October 2007)

doi:10.1038/nature06116

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

LL37 is the key trigger of pDC activation in psoriatic skin.

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Figure 2

LL37 converts self-DNA into a potent trigger of pDCs by forming aggregated and condensed structures.

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Figure 3

Self-DNA coupled with LL37 is translocated into pDCs and activates them through TLR9.

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Figure 4

LL37 retains DNA in early endocytic compartments of pDCs.

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