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Editorials

The long and winding road p377

German scientists must persevere in the stem-cell debate, despite the occasional setback.

doi:10.1038/449377a


Genome abuse p377

Citizens are right to resist government pressure to expand population DNA databases.

doi:10.1038/449377b


Toxic alert p378

A method of knocking out genes in mice needs more discrimination than many have recognized.

doi:10.1038/449378a


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Research Highlights

Research highlights p380

doi:10.1038/449380a


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Journal Club

Journal club p381

doi:10.1038/449381a


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News

Chemists poke holes in ozone theory p382

Reaction data of crucial chloride compounds called into question.

Quirin Schiermeier

doi:10.1038/449382a


Pressure for environmental disclosure increases p383

Companies urged to measure their carbon costs.

Jeff Tollefson

doi:10.1038/449383a


Sidelines p384

doi:10.1038/449384a


South African scheme lures in top talent p384

Government adds 51 research chairs to its universities.

Michael Cherry

doi:10.1038/449384b


Q&A: King of the stem cells p385

On 14 September, the California Institute for Regenerative Medicine (CIRM) appointed Australian biologist Alan Trounson as its new president. The CIRM has lacked a permanent director since neuroscientist Zach Hall departed in April, amidst rumours of tension between himself and Robert Klein, chair of the $3-billion agency's board.

Alan Trounson

doi:10.1038/449385a


Dropping a line from space p387

Tether offers down-to-Earth approach to payload delivery.

Katharine Sanderson

doi:10.1038/449387a


Stem-cell fraudster 'is working in Thailand' p387

Woo Suk Hwang may be back in the cloning lab.

David Cyranoski

doi:10.1038/449387b


Bacteria may be wiring up the soil p388

Microbes charge debate over nano networks.

Philip Ball

doi:10.1038/449388a


Stem cells by any other name p389

The US registry formerly known as 'embryonic'.

Monya Baker

doi:10.1038/449389a


Prospects power up for nuclear energy p390

doi:10.1038/449390a


Europe plots course for funding navigation system p390

doi:10.1038/449390b


HIV vaccine failure prompts Merck to halt trial p390

doi:10.1038/449390c


FDA poised for broader powers over drugs on sale p390

doi:10.1038/449390d


California universities maintain tobacco habit p390

doi:10.1038/449390e


Meteorite proves to be a hit in Peru p390

doi:10.1038/449390f


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News

Correction p390

doi:10.1038/449390g


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Column

Party of One

Passing the test p391

What role should the federal government have in pre-college science education? David Goldston looks at why the US Congress is acting now to help define that.

David Goldston

doi:10.1038/449391a


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Business

Copycat consolidation p393

As more blockbuster drugs come off patent, generic drugmakers face a changing landscape. Meredith Wadman looks at their strategies for survival.

Meredith Wadman

doi:10.1038/449393a


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News Features

The theatre: Bringing the past to life p395

Can a stage spectacular based on a TV documentary bring science to life and please the punters too? Brendan Maher joins a palaeontologist to watch the dinosaurs walk.

doi:10.1038/449395a

See also: Editor's summary


Environment: Riding on the roof of the world p398

China's railway to Tibet is an engineering marvel or an environmental menace — or perhaps both. Jane Qiu takes a ride to find out.

doi:10.1038/449398a

See also: Editor's summary


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Correspondence

Ocean pipes could help the Earth to cure itself p403

James E. Lovelock & Chris G. Rapley

doi:10.1038/449403a


H-index: however ranked, citations need context p403

Michael C. Wendl

doi:10.1038/449403b


H-index: age and sex make it unreliable p403

Clint D. Kelly & Michael D. Jennions

doi:10.1038/449403c


Conservationists could slip up in oil-palm enterprise p403

Reuben Clements & Mary Rose C. Posa

doi:10.1038/449403d


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Books and Arts

Research funding in the twenty-first century p405

Are universities and market forces compatible?

Michael M. Crow reviews Science for Sale: The Perils, Rewards and Delusions of Campus Capitalism by Daniel S. Greenberg

doi:10.1038/449405a


Atlas on our shoulders p406

Edvard I. Moser reviews The Body has a Mind of its Own: How Body Maps in Your Brain Help You Do (Almost) Everything Better by Sandra Blakeslee & Matthew Blakeslee

doi:10.1038/449406a


Ups and downs of a senator scientist p406

Salvatore Coen reviews The Volterra Chronicles: The Life and Times of an Extraordinary Mathematician 1860–1940 by Judith R. Goodstein

doi:10.1038/449406b


Oceanography fathomed p407

Arnold Gordon reviews To Follow the Water: Exploring the Ocean to Discover Climate by Dallas Murphy

doi:10.1038/449407a


Exhibition: The invisible continent p408

Emiliano Feresin

doi:10.1038/449408a

See also: Editor's summary


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News and Views

Environmental science: Forests and floods p409

One strategy for reducing catastrophic floods invokes protecting or regenerating forests that lie upstream of a threatened region. Support for this approach comes from a global-scale analysis of flood risk.

William F. Laurance

doi:10.1038/449409a


Immunology: Changed destiny p410

For practical and ethical reasons, researchers are on the lookout for ways to reprogramme one mature cell type into another. In one case, this might be as easy as switching off a single gene.

Huafeng Xie & Stuart H. Orkin

doi:10.1038/449410a

See also: Editor's summary


Nuclear physics: A non-disappearing magic trick p411

Well-established models of nuclei describe properties such as shells and magic numbers. But how do these predictions stand up to scrutiny for exotic, unstable nuclei? Pretty well, according to the latest study.

Ragnar Bengtsson & Peter Möller

doi:10.1038/449411a


Evolutionary biology: Development with a bite p413

Predictions drawn from experiments on the growth of molar teeth in mice, and applied to a wide range of related species, provide a remarkable connection between developmental and evolutionary biology.

P. David Polly

doi:10.1038/449413a

See also: Editor's summary


50 & 100 Years Ago p414

doi:10.1038/449414a


Quantum physics: Qubits ride the photon bus p415

Quantum mechanics using whole electrical circuits might seem a far-fetched idea. But make the circuits superconducting, and they can be used to send and collect single photons, rather like atoms do — only better.

Antti O. Niskanen & Yasunobu Nakamura

doi:10.1038/449415a

See also: Editor's summary


Genomics: Vine work p417

Charles Wenz

doi:10.1038/449417a

See also: Editor's summary


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Review

Taking dendritic cells into medicine p419

Ralph M. Steinman & Jacques Banchereau

doi:10.1038/nature06175

See also: Editor's summary


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Articles

Predicting evolutionary patterns of mammalian teeth from development p427

Kathryn D. Kavanagh, Alistair R. Evans & Jukka Jernvall

doi:10.1038/nature06153

See also: Editor's summary | News and Views by Polly


Enzymatic capture of an extrahelical thymine in the search for uracil in DNA p433

Jared B. Parker, Mario A. Bianchet, Daniel J. Krosky, Joshua I. Friedman, L. Mario Amzel & James T. Stivers

doi:10.1038/nature06131

See also: Editor's summary


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Letters

Coherent quantum state storage and transfer between two phase qubits via a resonant cavity p438

Mika A. Sillanpää, Jae I. Park & Raymond W. Simmonds

doi:10.1038/nature06124

See also: Editor's summary | News and Views by Niskanen & Nakamura


Coupling superconducting qubits via a cavity bus p443

J. Majer, J. M. Chow, J. M. Gambetta, Jens Koch, B. R. Johnson, J. A. Schreier, L. Frunzio, D. I. Schuster, A. A. Houck, A. Wallraff, A. Blais, M. H. Devoret, S. M. Girvin & R. J. Schoelkopf

doi:10.1038/nature06184

See also: Editor's summary | News and Views by Niskanen & Nakamura


Electronic and structural transitions in dense liquid sodium p448

Jean-Yves Raty, Eric Schwegler & Stanimir A. Bonev

doi:10.1038/nature06123

See also: Editor's summary


Millennial-scale trends in west Pacific warm pool hydrology since the Last Glacial Maximum p452

Judson W. Partin, Kim M. Cobb, Jess F. Adkins, Brian Clark & Diego P. Fernandez

doi:10.1038/nature06164

See also: Editor's summary


Metal saturation in the upper mantle p456

Arno Rohrbach, Chris Ballhaus, Ute Golla–Schindler, Peter Ulmer, Vadim S. Kamenetsky & Dmitry V. Kuzmin

doi:10.1038/nature06183


Fire and flood management of coastal swamp enabled first rice paddy cultivation in east China p459

Y. Zong, Z. Chen, J. B. Innes, C. Chen, Z. Wang & H. Wang

doi:10.1038/nature06135

See also: Editor's summary


The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla p463

Olivier Jaillon, Jean-Marc Aury, Benjamin Noel, Alberto Policriti, Christian Clepet, Alberto Casagrande, Nathalie Choisne, Sébastien Aubourg, Nicola Vitulo, Claire Jubin, Alessandro Vezzi, Fabrice Legeai, Philippe Hugueney, Corinne Dasilva, David Horner, Erica Mica, Delphine Jublot, Julie Poulain, Clémence Bruyère, Alain Billault, Béatrice Segurens, Michel Gouyvenoux, Edgardo Ugarte, Federica Cattonaro, Véronique Anthouard, Virginie Vico, Cristian Del Fabbro, Michaël Alaux, Gabriele Di Gaspero, Vincent Dumas, Nicoletta Felice, Sophie Paillard, Irena Juman, Marco Moroldo, Simone Scalabrin, Aurélie Canaguier, Isabelle Le Clainche, Giorgio Malacrida, Eléonore Durand, Graziano Pesole, Valérie Laucou, Philippe Chatelet, Didier Merdinoglu, Massimo Delledonne, Mario Pezzotti, Alain Lecharny, Claude Scarpelli, François Artiguenave, M. Enrico Pè, Giorgio Valle, Michele Morgante, Michel Caboche, Anne-Françoise Adam-Blondon, Jean Weissenbach, Francis Quétier & Patrick Wincker for The French–Italian Public Consortium for Grapevine Genome Characterization 

doi:10.1038/nature06148

See also: Editor's summary | News and Views by Wenz


Genetic variation in a human odorant receptor alters odour perception p468

Andreas Keller, Hanyi Zhuang, Qiuyi Chi, Leslie B. Vosshall & Hiroaki Matsunami

doi:10.1038/nature06162

See also: Editor's summary


Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors p473

César Cobaleda, Wolfram Jochum & Meinrad Busslinger

doi:10.1038/nature06159

See also: Editor's summary | News and Views by Xie & Orkin


IgH class switching and translocations use a robust non-classical end-joining pathway p478

Catherine T. Yan, Cristian Boboila, Ellen Kris Souza, Sonia Franco, Thomas R. Hickernell, Michael Murphy, Sunil Gumaste, Mark Geyer, Ali A. Zarrin, John P. Manis, Klaus Rajewsky & Frederick W. Alt

doi:10.1038/nature06020


Rag mutations reveal robust alternative end joining p483

Barbara Corneo, Rebecca L. Wendland, Ludovic Deriano, Xiaoping Cui, Isaac A. Klein, Serre-Yu Wong, Suzzette Arnal, Abigail J. Holub, Geoffrey R. Weller, Bette A. Pancake, Sundeep Shah, Vicky L. Brandt, Katheryn Meek & David B. Roth

doi:10.1038/nature06168


Structural basis of Dscam isoform specificity p487

Rob Meijers, Roland Puettmann-Holgado, Georgios Skiniotis, Jin-huan Liu, Thomas Walz, Jia-huai Wang & Dietmar Schmucker

doi:10.1038/nature06147


Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1 p492

Gabriele A. Amodeo, Michael J. Rudolph & Liang Tong

doi:10.1038/nature06127


Structural basis for AMP binding to mammalian AMP-activated protein kinase p496

Bing Xiao, Richard Heath, Peter Saiu, Fiona C. Leiper, Philippe Leone, Chun Jing, Philip A. Walker, Lesley Haire, John F. Eccleston, Colin T. Davis, Stephen R. Martin, David Carling & Steven J. Gamblin

doi:10.1038/nature06161


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Naturejobs

Prospect

Prospects p501

Paul Smaglik

doi:10.1038/nj7161-501a


Region

Enter the dragon p502

Once a poor village, Shenzhen is now one of the wealthiest cities in China. David Cyranoski learns its plans for the future.

David Cyranoski

doi:10.1038/nj7161-502a


Highlights

Highlight on Ireland

doi:10.1038/nj0179


Spotlights

Spotlight on Northern Virginia and Maryland

doi:10.1038/nj0180


Spotlight on Shenzhen

doi:10.1038/nj0181


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Futures

Alloy p506

An identity crisis.

Marissa Lingen

doi:10.1038/449506a


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