For practical and ethical reasons, researchers are on the lookout for ways to reprogramme one mature cell type into another. In one case, this might be as easy as switching off a single gene.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Okita, K., Ichisaka, T. & Yamanaka, S. Nature 448, 313–317 (2007).
Wernig, M. et al. Nature 448, 318–324 (2007).
Maherali, N. et al. Cell Stem Cell 1, 55–70 (2007).
Cobaleda, C., Jochum, W. & Busslinger, M. Nature 449, 473–477 (2007).
Orkin, S. H. Nature Rev. Genet. 1, 57–64 (2000).
Graf, T. Blood 99, 3089–3101 (2002).
Laiosa, C. V. et al. Immunity 25, 731–744 (2006).
Xie, H., Ye, M., Feng, R. & Graf, T. Cell 117, 663–676 (2004).
Iwasaki, H. et al. Immunity 19, 451–462 (2003).
Rolink, A. G., Nutt, S. L., Melchers, F. & Busslinger, M. Nature 401, 603–606 (1999).
Nutt, S. L., Heavey, B., Rolink, A. G. & Busslinger, M. Nature 401, 556–562 (1999).
Horcher, M., Souabni, A. & Busslinger, M. Immunity 14, 779–790 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Xie, H., Orkin, S. Changed destiny. Nature 449, 410–411 (2007). https://doi.org/10.1038/449410a
Published:
Issue Date:
DOI: https://doi.org/10.1038/449410a
