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News and Views
Nature 449, 410-411 (27 September 2007) | doi:10.1038/449410a; Published online 26 September 2007
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Immunology: Changed destiny
Huafeng Xie1 & Stuart H. Orkin1
Abstract
For practical and ethical reasons, researchers are on the lookout for ways to reprogramme one mature cell type into another. In one case, this might be as easy as switching off a single gene.
The norm is for most undifferentiated, progenitor cells to irreversibly mature into one particular type of cell. But some cells, even after commitment to a specific fate, can acquire properties of an entirely different cell through a process called cellular reprogramming.
- Huafeng Xie and Stuart H. Orkin are in the Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Email: stuart_orkin@dfci.harvard.edu
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