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Editorial
Nature 449, 378 (27 September 2007) | doi:10.1038/449378a; Published online 26 September 2007
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Abstract
A method of knocking out genes in mice needs more discrimination than many have recognized.
One of the most common ways to investigate the role of a gene in human physiology is to delete its equivalent from a mouse genome and to observe the effect. The use of one enzyme in particular, the recombinase 'Cre', has revolutionized the study of gene function in mice.
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