Supplementary information

From the following article:

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

Laura E. Parton, Chian Ping Ye, Roberto Coppari, Pablo J. Enriori, Brian Choi, Chen-Yu Zhang, Chun Xu, Claudia R. Vianna, Nina Balthasar, Charlotte E. Lee, Joel K. Elmquist, Michael A. Cowley & Bradford B. Lowell

Nature 449, 228-232(13 September 2007)

doi:10.1038/nature06098

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Supplementary Information

This file contains Supplementary Data with a full description of studies used to characterize the ATP sensitivity of both wild-type and mutKir6.2 POMC neurons in addition to whole-cell recordings showing effects of glucose, genipin and leptin. Also, Supplementary Figure S1 displays RT-PCR results showing tissue specific expression of mutKir6.2 and characterization of KATP channels in mutKir6.2 POMC neurons; and Supplementary Figure S2 displays whole cell electrophysiological recordings of wild-type and mutKir6.2 POMC neurons showing effects of glucose, genipin and leptin.

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