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Nature 449, 228-232 (29 August 2007) | doi:10.1038/nature06098;
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Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
A subset of neurons in the brain, known as |[lsquo]|glucose-excited|[rsquo]| neurons, depolarize and increase their firing rate in response to increases in extracellular glucose. Similar to insulin secretion by pancreatic |[bgr]|-cells, glucose excitation of neurons is driven by ATP-mediated closure of ATP-sensitive potassium (KATP) channels.
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