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Nature 449, 148-149 (13 September 2007) | doi:10.1038/449148a; Published online 12 September 2007
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Epigenetics: Perceptive enzymes
Anne C. Ferguson-Smith1 & John M. Greally2
Abstract
Adding methyl groups to DNA is a way of regulating some genes and genomic sequences. Structural analysis reveals that the enzyme complex that mediates this process shows unexpected sequence specificity.
Imprinted genes are a small but developmentally important set of genes whose expression depends on the parent from which they are inherited. So, for some of these genes only the maternally inherited copy is expressed, and for others only the copy inherited from the father is expressed.
- Anne C. Ferguson-Smith is in the Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
Email: afsmith@mole.bio.cam.ac.uk - John M. Greally is in the Departments of Medicine (Hematology) and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Email: jgreally@aecom.yu.edu
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