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Nature 449, 126 (13 September 2007) | doi:10.1038/449126a; Published online 12 September 2007

Interferon discovery and ferret flu

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Jean Lindenmann, who discovered how inactivated viruses help to protect cells, talks to Alison Abbott about his career.

Fifty years ago virologists were struggling to understand why an inactivated virus reduced the ability of a normal virus to infect cells — a process called interference. Jean Lindenmann and Alick Isaacs at the National Institute for Medical Research (NIMR) at Mill Hill, London, found the answer in less than a year of intensive and inspired research1, 2.