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From the following article:

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

Laura E. Parton, Chian Ping Ye, Roberto Coppari, Pablo J. Enriori, Brian Choi, Chen-Yu Zhang, Chun Xu, Claudia R. Vianna, Nina Balthasar, Charlotte E. Lee, Joel K. Elmquist, Michael A. Cowley & Bradford B. Lowell

Nature 449, 228-232(13 September 2007)

doi:10.1038/nature06098

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Glucose sensing is lost in POMC-mut-Kir6.2 neurons.

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Figure 2

Glucose-sensing is lost in POMC neurons of mice on a high-fat diet.

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Figure 3

Genipin activates glucose-excited POMC neurons.

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Figure 4

Acute inhibition or genetic deletion of UCP2 restores or prevents loss of glucose sensing in POMC neurons as a result of obesity induced by a high-fat diet.

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