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News and Views
Nature 449, 29-30 (6 September 2007) | doi:10.1038/449029a; Published online 5 September 2007
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HIV/AIDS: Allied responses
John R. Mascola1
Abstract
The main function of neutralizing antibodies is to block viral entry into host cells. But, for maximal protection against HIV, such antibodies must call upon other elements of the immune system to help with the job.
More than two decades into the AIDS pandemic, and despite intense research on the human immunodeficiency virus (HIV), we still do not have a vaccine to prevent HIV infection. One possibility is to trigger the components of adaptive (specific) immunity1 — T cells and B-cell-derived antibodies.
- John R. Mascola is at the Vaccine Research Center, NIAID, NIH, 40 Convent Drive, MSC 3015, Bethesda, Maryland 20892, USA.
Email: jmascola@nih.gov
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