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From the following article:

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

Giovanni D'Angelo, Elena Polishchuk, Giuseppe Di Tullio, Michele Santoro, Antonella Di Campli, Anna Godi, Gun West, Jacek Bielawski, Chia-Chen Chuang, Aarnoud C. van der Spoel, Frances M. Platt, Yusuf A. Hannun, Roman Polishchuk, Peter Mattjus & Maria Antonietta De Matteis

Nature 449, 62-67(6 September 2007)

doi:10.1038/nature06097

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

FAPP2 is a GlcCer-transfer protein.

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Figure 2

FAPP2 is required for complex GSL synthesis.

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Figure 3

GSL synthesis depends on PtdIns4P, and not on membrane trafficking at the GC.

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Figure 4

Model of FAPP2 mechanism of action.

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