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Nature 448, 1063-1067 (30 August 2007) | doi:10.1038/nature06055;
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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
The acetyl-transferase Tip60 might influence tumorigenesis in multiple ways. First, Tip60 is a co-regulator of transcription factors that either promote or suppress tumorigenesis, such as Myc and p53.
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Abstract
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