Editor's Summary
30 August 2007
Tip60 as an oncogene
The acetyl-transferase Tip60 regulates transcription and is involved in the DNA damage response. Now it has been found to have tumour suppressor activity in vivo both in a mouse model and in human tumours. The human Tip60 locus (HTATIP) is frequently mutated in head and neck squamous cell carcinoma, breast carcinoma and lymphomas. Nuclear Tip60 staining on tissue microarrays is lost in a variety of tumours, and most significantly in breast carcinomas. This work suggests that critical levels of Tip60 are required for mounting an oncogene-induced DNA damage response in incipient tumour cells: the failure of this defence mechanism may synergize with p53 mutation towards tumour progression.
Letter: Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Chiara Gorrini, Massimo Squatrito, Chiara Luise, Nelofer Syed, Daniele Perna, Landon Wark, Francesca Martinato, Domenico Sardella, Alessandro Verrecchia, Samantha Bennett, Stefano Confalonieri, Matteo Cesaroni, Francesco Marchesi, Milena Gasco, Eugenio Scanziani, Maria Capra, Sabine Mai, Paolo Nuciforo, Tim Crook, John Lough & Bruno Amati
doi:10.1038/nature06055
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