Editor's Summary

30 August 2007

Putting mice on the HapMap

A major new resource is now available to geneticists working on the many mouse models that are used to study toxicity and human disease. The genomes of four wild-derived and eleven inbred laboratory mouse strains have been resequenced to create a comprehensive resource of DNA variation. About 8.3 million single base-pair differences known as single nucleotide polymorphisms (SNPs) were identified. The data are publicly available as a mouse 'HapMap' at http://mouse.perlegen.com/. The density and quality of this set of SNP markers is unprecedented for a mammalian genome, and it will provide a powerful tool for identifying the genetic determinants of phenotypic variation in the mouse.

Letter: A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

Kelly A. Frazer, Eleazar Eskin, Hyun Min Kang, Molly A. Bogue, David A. Hinds, Erica J. Beilharz, Robert V. Gupta, Julie Montgomery, Matt M. Morenzoni, Geoffrey B. Nilsen, Charit L. Pethiyagoda, Laura L. Stuve, Frank M. Johnson, Mark J. Daly, Claire M. Wade & David R. Cox

doi:10.1038/nature06067

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