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Nature 448, xiii (23 August 2007) | doi:10.1038/7156xiiia; Published online 22 August 2007

Making the paper: Guoping Feng

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Loss of one brain protein causes compulsive grooming in mice.

People with obsessive-compulsive disorder (OCD) repeat ritualistic actions such as hand washing or checking locks so frequently that it interferes with their everyday lives. But although the symptoms of the disease are obvious, its causes are not.